Protein-losing enteropathy (PLE) is a severe Fontan complication. This is a case report of the first hybridtreatment of PLE in Denmark of an 11-year-old Fontan patient with severe symptoms (diarrhoea, fatigue andswelling) and low albumin level. Diagnostics included intranodal and intrahepatic dynamic contrast magneticresonance lymphangiography. The hybrid intervention consisted of selective lymphatic duct embolisation andinnominate vein turn-down to treat PLE. The interventions went well, and two months after discharge thepatient was relieved from PLE symptoms, the albumin level was normalised, and the patient felt more energetic.