HLA-G genotype is associated with fetoplacental growth
Research output: Contribution to journal › Journal article › Research › peer-review
The human leukocyte antigen (HLA)-G is expressed by extravillous cytotrophoblast cells in the feto-maternal contact zone. Polymorphisms have been described in the HLA-G gene and have been linked with differences in HLA-G mRNA alternative splicing patterns and protein expression. Differences in the isoform profile or the degree of HLA-G expression may influence cytokine production and, thereby, placental and fetal growth. Associations between a 14 bp deletion polymorphism in the 3'UTR part of the HLA-G gene and birth weight in relation to gestational age and placental weight were studied in 47 pregnancies complicated with preeclampsia and 87 with no preeclampsia. An HLA-G genotype homozygous for the presence of the 14 bp sequence polymorphism was significantly associated with increased birth weight in relation to gestational age (one-way analysis of variance; 2 degrees of freedom: p = 0.02) and with placental weight at birth (>38 weeks of gestation; +14 bp/+14 bp vs others; unpaired t-test: p = 0.03). There was also a slightly higher placental ratio in the offspring with the +14 bp/+14 bp genotype. The implications of these findings are discussed in relation to certain complications of pregnancy and in an evolutionary perspective.
Original language | English |
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Journal | Human Immunology |
Volume | 65 |
Issue number | 6 |
Pages (from-to) | 586-93 |
Number of pages | 8 |
ISSN | 0198-8859 |
DOIs | |
Publication status | Published - Jun 2004 |
- Alternative Splicing, Birth Weight, Female, Fetus, Gestational Age, HLA Antigens, HLA-G Antigens, Histocompatibility Antigens Class I, Humans, Placenta, Placentation, Polymorphism, Genetic, Pre-Eclampsia, Pregnancy, Sequence Deletion, Trophoblasts, Journal Article, Research Support, Non-U.S. Gov't
Research areas
ID: 188691744