HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave

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HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave. / COMMIT-KZN Team.

In: eLife, Vol. 10, e67397, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

COMMIT-KZN Team 2021, 'HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave', eLife, vol. 10, e67397. https://doi.org/10.7554/eLife.67397

APA

COMMIT-KZN Team (2021). HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave. eLife, 10, [e67397]. https://doi.org/10.7554/eLife.67397

Vancouver

COMMIT-KZN Team. HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave. eLife. 2021;10. e67397. https://doi.org/10.7554/eLife.67397

Author

COMMIT-KZN Team. / HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave. In: eLife. 2021 ; Vol. 10.

Bibtex

@article{278d572f9c384789a44f7d3542c9891e,
title = "HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave",
abstract = "There are conicting reports on the effects of HIV on COVID-19. Here we analyzed disease severity and immune cell changes during and after SARS-CoV-2 infection in participants from South Africa, of which 39% were people living with HIV (PLWH), during the first and second (beta dominated) infection waves. The second wave had more PLWH requiring supplemental oxygen relative to HIV negative participants. Higher disease severity was associated with low CD4 T cell counts and higher neutrophil to lymphocyte ratios (NLR). Yet, CD4 counts recovered and NLR stabilized after SARS-CoV-2 clearance in wave 2 infected PLWH, arguing for an interaction between SARS-CoV-2 and HIV infection leading to low CD4 and high NLR. The first infection wave, where severity in HIV negative and PLWH was similar, still showed some HIV modulation of SARS-CoV-2 immune responses. Therefore, HIV infection can synergize with the SARS-CoV-2 variant to change COVID-19 outcomes.",
author = "Farina Karim and Inbal Gazy and Sandile Cele and Yenzekile Zungu and Robert Krause and Mallory Bernstein and Khadija Khan and Yashica Ganga and Hylton Rodel and Ntombifuthi Mthabela and Matilda Mazibuko and Daniel Muema and Dirhona Ramjit and Thumbi Ndung{\textquoteright}U and Willem Hanekom and Gosnell, {Bernadett I.} and Lessells, {Richard J.} and Emily Wong and {De Oliveira}, Tulio and Moosa, {Mahomed Yunus S.} and Gila Lustig and Alasdair Leslie and Henrik Kl{\o}verpris and Alex Sigal and {COMMIT-KZN Team}",
note = "Publisher Copyright: {\textcopyright} Farina Karim 2021.",
year = "2021",
doi = "10.7554/eLife.67397",
language = "English",
volume = "10",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - HIV status alters disease severity and immune cell responses in beta variant sars-COV-2 infection wave

AU - Karim, Farina

AU - Gazy, Inbal

AU - Cele, Sandile

AU - Zungu, Yenzekile

AU - Krause, Robert

AU - Bernstein, Mallory

AU - Khan, Khadija

AU - Ganga, Yashica

AU - Rodel, Hylton

AU - Mthabela, Ntombifuthi

AU - Mazibuko, Matilda

AU - Muema, Daniel

AU - Ramjit, Dirhona

AU - Ndung’U, Thumbi

AU - Hanekom, Willem

AU - Gosnell, Bernadett I.

AU - Lessells, Richard J.

AU - Wong, Emily

AU - De Oliveira, Tulio

AU - Moosa, Mahomed Yunus S.

AU - Lustig, Gila

AU - Leslie, Alasdair

AU - Kløverpris, Henrik

AU - Sigal, Alex

AU - COMMIT-KZN Team

N1 - Publisher Copyright: © Farina Karim 2021.

PY - 2021

Y1 - 2021

N2 - There are conicting reports on the effects of HIV on COVID-19. Here we analyzed disease severity and immune cell changes during and after SARS-CoV-2 infection in participants from South Africa, of which 39% were people living with HIV (PLWH), during the first and second (beta dominated) infection waves. The second wave had more PLWH requiring supplemental oxygen relative to HIV negative participants. Higher disease severity was associated with low CD4 T cell counts and higher neutrophil to lymphocyte ratios (NLR). Yet, CD4 counts recovered and NLR stabilized after SARS-CoV-2 clearance in wave 2 infected PLWH, arguing for an interaction between SARS-CoV-2 and HIV infection leading to low CD4 and high NLR. The first infection wave, where severity in HIV negative and PLWH was similar, still showed some HIV modulation of SARS-CoV-2 immune responses. Therefore, HIV infection can synergize with the SARS-CoV-2 variant to change COVID-19 outcomes.

AB - There are conicting reports on the effects of HIV on COVID-19. Here we analyzed disease severity and immune cell changes during and after SARS-CoV-2 infection in participants from South Africa, of which 39% were people living with HIV (PLWH), during the first and second (beta dominated) infection waves. The second wave had more PLWH requiring supplemental oxygen relative to HIV negative participants. Higher disease severity was associated with low CD4 T cell counts and higher neutrophil to lymphocyte ratios (NLR). Yet, CD4 counts recovered and NLR stabilized after SARS-CoV-2 clearance in wave 2 infected PLWH, arguing for an interaction between SARS-CoV-2 and HIV infection leading to low CD4 and high NLR. The first infection wave, where severity in HIV negative and PLWH was similar, still showed some HIV modulation of SARS-CoV-2 immune responses. Therefore, HIV infection can synergize with the SARS-CoV-2 variant to change COVID-19 outcomes.

U2 - 10.7554/eLife.67397

DO - 10.7554/eLife.67397

M3 - Journal article

C2 - 34608862

AN - SCOPUS:85118492604

VL - 10

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e67397

ER -

ID: 284702567