Higher burden of supraventricular ectopic complexes early after catheter ablation for atrial fibrillation is associated with increased risk of recurrent atrial fibrillation

Research output: Contribution to journalJournal articleResearchpeer-review

  • Christina Alhede
  • Arne Johannessen
  • Dixen, Ulrik
  • Jan S. Jensen
  • Pekka Raatikainen
  • Gerhard Hindricks
  • Håkan Walfridsson
  • Ole Kongstad
  • Steen Pehrson
  • Anders Englund
  • Juha Hartikainen
  • Peter S. Hansen
  • Jens C. Nielsen
  • Christian Jons

Early identification of patients who could benefit from early re-intervention after catheter ablation is highly warranted. Our aim was to investigate the association between post-procedural burden of supraventricular ectopic complexes (SVEC) and the risk of long-term atrial fibrillation (AF) recurrence. A total of 125 patients undergoing catheter ablation for AF were included. Patients underwent 7-day Holter recordings immediately post-procedural. The number of SVEC in post-procedural Holter recordings was categorized into quartiles: 0-72, 73-212, 213-782 and≥783 SVEC/day. Long-term AF recurrence was defined as a combined endpoint of AF≥1 min during follow-up Holter recordings, cardioversion or hospitalization for AF after a 3-month blanking period and within 24 months of follow-up. High post-procedural supraventricular ectopy burden was associated with an increased risk of long-term AF recurrence in a dose-dependent manner (≥783 SVEC: HR 4.6 [1.9-11.5], P<0.001) irrespective of AF recurrence during the blanking period or other risk factors. In patients with early AF recurrence<90 days after catheter ablation ectopy burden was also highly predictive of long-term AF recurrence (SVEC≥213: HR 3.0 [1.3-6.7], P=0.007). Correspondingly, patients with early AF recurrence but low ectopy burden remained at low risk of long-term AF recurrence after the blanking period. Our results indicate that post-procedural ectopy burden is highly associated with long-term AF recurrence and could be a potent risk marker for selection of patients for early re-ablation. Development of future ablation risk stratification and strategies should include focus on post-procedural ectopy burden.

Original languageEnglish
Issue number1
Pages (from-to)50-57
Number of pages8
Publication statusPublished - 2018

    Research areas

  • Arrhythmia, Atrial fibrillation, Atrial premature complexes, Recurrence, Treatment

ID: 217697709