High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women. / Magistrado, Pamela A; Minja, Daniel; Doritchamou, Justin; Ndam, Nicaise Tuikue; John, Davis; Schmiegelow, Christentze; Massougbodji, Achille; Dahlbäck, Madeleine; Ditlev, Sisse B; Pinto, Vera V; Resende, Mafalda; Lusingu, John; Theander, Thor G; Salanti, Ali; Nielsen, Morten A.

In: Vaccine, Vol. 29, No. 3, 2011, p. 437-43.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Magistrado, PA, Minja, D, Doritchamou, J, Ndam, NT, John, D, Schmiegelow, C, Massougbodji, A, Dahlbäck, M, Ditlev, SB, Pinto, VV, Resende, M, Lusingu, J, Theander, TG, Salanti, A & Nielsen, MA 2011, 'High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women', Vaccine, vol. 29, no. 3, pp. 437-43. https://doi.org/10.1016/j.vaccine.2010.10.080

APA

Magistrado, P. A., Minja, D., Doritchamou, J., Ndam, N. T., John, D., Schmiegelow, C., Massougbodji, A., Dahlbäck, M., Ditlev, S. B., Pinto, V. V., Resende, M., Lusingu, J., Theander, T. G., Salanti, A., & Nielsen, M. A. (2011). High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women. Vaccine, 29(3), 437-43. https://doi.org/10.1016/j.vaccine.2010.10.080

Vancouver

Magistrado PA, Minja D, Doritchamou J, Ndam NT, John D, Schmiegelow C et al. High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women. Vaccine. 2011;29(3):437-43. https://doi.org/10.1016/j.vaccine.2010.10.080

Author

Magistrado, Pamela A ; Minja, Daniel ; Doritchamou, Justin ; Ndam, Nicaise Tuikue ; John, Davis ; Schmiegelow, Christentze ; Massougbodji, Achille ; Dahlbäck, Madeleine ; Ditlev, Sisse B ; Pinto, Vera V ; Resende, Mafalda ; Lusingu, John ; Theander, Thor G ; Salanti, Ali ; Nielsen, Morten A. / High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women. In: Vaccine. 2011 ; Vol. 29, No. 3. pp. 437-43.

Bibtex

@article{c078cbee630a46c888cd09b7ab8f4aec,

title = "High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women",

abstract = "Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4¿ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4¿ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.",

author = "Magistrado, {Pamela A} and Daniel Minja and Justin Doritchamou and Ndam, {Nicaise Tuikue} and Davis John and Christentze Schmiegelow and Achille Massougbodji and Madeleine Dahlb{\"a}ck and Ditlev, {Sisse B} and Pinto, {Vera V} and Mafalda Resende and John Lusingu and Theander, {Thor G} and Ali Salanti and Nielsen, {Morten A}",

year = "2011",

doi = "10.1016/j.vaccine.2010.10.080",

language = "English",

volume = "29",

pages = "437--43",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - High efficacy of anti DBL4e-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

AU - Magistrado, Pamela A

AU - Minja, Daniel

AU - Doritchamou, Justin

AU - Ndam, Nicaise Tuikue

AU - John, Davis

AU - Schmiegelow, Christentze

AU - Massougbodji, Achille

AU - Dahlbäck, Madeleine

AU - Ditlev, Sisse B

AU - Pinto, Vera V

AU - Resende, Mafalda

AU - Lusingu, John

AU - Theander, Thor G

AU - Salanti, Ali

AU - Nielsen, Morten A

PY - 2011

Y1 - 2011

N2 - Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4¿ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4¿ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.

AB - Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4¿ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4¿ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.

U2 - 10.1016/j.vaccine.2010.10.080

DO - 10.1016/j.vaccine.2010.10.080

M3 - Journal article

C2 - 21075162

VL - 29

SP - 437

EP - 443

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 3

ER -

ID: 32444977