Heterogeneity and plasticity of epidermal stem cells
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Heterogeneity and plasticity of epidermal stem cells. / Schepeler, Troels; Page, Mahalia E; Jensen, Kim Bak.
In: Development (Cambridge, England), Vol. 141, No. 13, 07.2014, p. 2559-2567.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Heterogeneity and plasticity of epidermal stem cells
AU - Schepeler, Troels
AU - Page, Mahalia E
AU - Jensen, Kim Bak
N1 - © 2014. Published by The Company of Biologists Ltd.
PY - 2014/7
Y1 - 2014/7
N2 - The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task. In this Review, we discuss stem cell behaviour during normal tissue homeostasis, regeneration and disease within the pilosebaceous unit, an integral structure of the epidermis that is responsible for hair growth and lubrication of the epithelium. We provide an up-to-date view of the pilosebaceous unit, encompassing the heterogeneity and plasticity of multiple discrete stem cell populations that are strongly influenced by external cues to maintain their identity and function.
AB - The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task. In this Review, we discuss stem cell behaviour during normal tissue homeostasis, regeneration and disease within the pilosebaceous unit, an integral structure of the epidermis that is responsible for hair growth and lubrication of the epithelium. We provide an up-to-date view of the pilosebaceous unit, encompassing the heterogeneity and plasticity of multiple discrete stem cell populations that are strongly influenced by external cues to maintain their identity and function.
U2 - 10.1242/dev.104588
DO - 10.1242/dev.104588
M3 - Review
C2 - 24961797
VL - 141
SP - 2559
EP - 2567
JO - Development
JF - Development
SN - 0950-1991
IS - 13
ER -
ID: 118031559