We present a novel method to analyze the growth of abdominal atherosclerotic plaques based on x-ray projections. The growth analysis can aid progression monitoring in clinical trials and in population screening programs. Our results are based on a longitudinal study over 8.5 years. The annotations of the calcifications are matched longitudinally using thin plate spline registration and area overlap calculations.

The growth of the calcifications is measured by the distribution of the geometry statistics of the calcifications.

The method was evaluated on 135 subjects with a total number of 611 calcifications. Our results show, for instance longitudinal growth of calcifications with a mean of 2.53 mm ($\pm$ 1.95) in the blood flow direction and correlations with pathologically related biomarkers.