Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain. / Falk, Sarah; Gallego-Pedersen, Simone ; Petersen, Nicolas Caesar.

In: In Vivo, Vol. 31, No. 4, 07.2017, p. 619-623.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Falk, S, Gallego-Pedersen, S & Petersen, NC 2017, 'Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain', In Vivo, vol. 31, no. 4, pp. 619-623. https://doi.org/10.21873/invivo.11102

APA

Falk, S., Gallego-Pedersen, S., & Petersen, N. C. (2017). Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain. In Vivo, 31(4), 619-623. https://doi.org/10.21873/invivo.11102

Vancouver

Falk S, Gallego-Pedersen S, Petersen NC. Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain. In Vivo. 2017 Jul;31(4):619-623. https://doi.org/10.21873/invivo.11102

Author

Falk, Sarah ; Gallego-Pedersen, Simone ; Petersen, Nicolas Caesar. / Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain. In: In Vivo. 2017 ; Vol. 31, No. 4. pp. 619-623.

Bibtex

@article{3bc0036830ef44f6a1d00748dfbdd399,
title = "Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain",
abstract = "Despite affecting millions of people, chronic pain is generally treated insufficiently. A major point of focus has been the lack of translation from preclinical data to clinical results, with the predictive value of chronic pain models being a major concern. In contrast to current focus on stimulus-based nociceptive responses in preclinical research, development of behavioural tests designed to quantify suspension of normal behaviour is likely a more equivalent readout for human pain-assessment tests. In this study, we quantified grid-climbing behaviour as a non-stimulus-evoked behavioural test for potential use as a measure of neuropathic and cancer-induced bone pain in mice. In both models, the grid-climbing test demonstrated pain-related sparing of the affected leg during climbing. In both models, the behaviour was reversed by administration of morphine, suggesting that the observed behaviour was pain-specific.",
author = "Sarah Falk and Simone Gallego-Pedersen and Petersen, {Nicolas Caesar}",
year = "2017",
month = jul,
doi = "10.21873/invivo.11102",
language = "English",
volume = "31",
pages = "619--623",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "4",

}

RIS

TY - JOUR

T1 - Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain

AU - Falk, Sarah

AU - Gallego-Pedersen, Simone

AU - Petersen, Nicolas Caesar

PY - 2017/7

Y1 - 2017/7

N2 - Despite affecting millions of people, chronic pain is generally treated insufficiently. A major point of focus has been the lack of translation from preclinical data to clinical results, with the predictive value of chronic pain models being a major concern. In contrast to current focus on stimulus-based nociceptive responses in preclinical research, development of behavioural tests designed to quantify suspension of normal behaviour is likely a more equivalent readout for human pain-assessment tests. In this study, we quantified grid-climbing behaviour as a non-stimulus-evoked behavioural test for potential use as a measure of neuropathic and cancer-induced bone pain in mice. In both models, the grid-climbing test demonstrated pain-related sparing of the affected leg during climbing. In both models, the behaviour was reversed by administration of morphine, suggesting that the observed behaviour was pain-specific.

AB - Despite affecting millions of people, chronic pain is generally treated insufficiently. A major point of focus has been the lack of translation from preclinical data to clinical results, with the predictive value of chronic pain models being a major concern. In contrast to current focus on stimulus-based nociceptive responses in preclinical research, development of behavioural tests designed to quantify suspension of normal behaviour is likely a more equivalent readout for human pain-assessment tests. In this study, we quantified grid-climbing behaviour as a non-stimulus-evoked behavioural test for potential use as a measure of neuropathic and cancer-induced bone pain in mice. In both models, the grid-climbing test demonstrated pain-related sparing of the affected leg during climbing. In both models, the behaviour was reversed by administration of morphine, suggesting that the observed behaviour was pain-specific.

U2 - 10.21873/invivo.11102

DO - 10.21873/invivo.11102

M3 - Journal article

C2 - 28652428

VL - 31

SP - 619

EP - 623

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 4

ER -

ID: 180400257