Green microfluidic liquid-phase microextraction of polar and non-polar acids from urine
Research output: Contribution to journal › Journal article › Research › peer-review
In this work, hippuric acid (log P = 0.5), anthranilic acid (log P = 1.3), ketoprofen (log P = 3.6), and naproxen (log P = 3.0) were simultaneously extracted by a green microfluidic device based on the principles of liquid-phase microextraction (LPME). Different deep eutectic solvents (DESs) were investigated as supported liquid membrane (SLM), and a mixture of camphor and menthol as eutectic solvents in the molar ratio 1:1 was found to be highly efficient for the simultaneous extraction of non-polar and polar acidic drugs. LPME was conducted for 6 min per sample. Urine sample was delivered to the system at 1 μL min−1, and target analytes were extracted exhaustively (75–100% recovery) across the DES SLM, and into pure aqueous phosphate buffer pH 11.0 delivered as acceptor at 1 μL min−1. The acceptor was analyzed with liquid chromatography-UV detection. Interestingly, the DES enabled extraction of both the polar and non-polar model analytes at the same time; all chemicals were green and non-hazardous, and the chemical waste was less than 1 mg per sample.
Original language | English |
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Journal | Analytical and Bioanalytical Chemistry |
Volume | 413 |
Pages (from-to) | 3717–3723 |
ISSN | 1618-2642 |
DOIs | |
Publication status | Published - 2021 |
Externally published | Yes |
- Acidic drugs, Deep eutectic solvents, Liquid-phase microextraction, Microfluidic, Supported liquid membrane
Research areas
ID: 261452524