Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys

Research output: Contribution to journal › Journal article › Research › peer-review

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Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys. / Darusman, Huda S.; Agungpriyono, Dewi Ratih; Kusumaputri, Vinka A.; Sajuthi, Dondin; Schapiro, Steven J.; Hau, Jann.

In: Frontiers in Aging Neuroscience, Vol. 11, 50, 07.03.2019, p. 1-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Darusman, HS, Agungpriyono, DR, Kusumaputri, VA, Sajuthi, D, Schapiro, SJ & Hau, J 2019, 'Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys', Frontiers in Aging Neuroscience, vol. 11, 50, pp. 1-5. https://doi.org/10.3389/fnagi.2019.00050

APA

Darusman, H. S., Agungpriyono, D. R., Kusumaputri, V. A., Sajuthi, D., Schapiro, S. J., & Hau, J. (2019). Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys. Frontiers in Aging Neuroscience, 11, 1-5. [50]. https://doi.org/10.3389/fnagi.2019.00050

Vancouver

Darusman HS, Agungpriyono DR, Kusumaputri VA, Sajuthi D, Schapiro SJ, Hau J. Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys. Frontiers in Aging Neuroscience. 2019 Mar 7;11:1-5. 50. https://doi.org/10.3389/fnagi.2019.00050

Author

Darusman, Huda S. ; Agungpriyono, Dewi Ratih ; Kusumaputri, Vinka A. ; Sajuthi, Dondin ; Schapiro, Steven J. ; Hau, Jann. / Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys. In: Frontiers in Aging Neuroscience. 2019 ; Vol. 11. pp. 1-5.

Bibtex

@article{fd00ecdda784488aa611d57ac8498d83,
title = "Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys",
abstract = "Neurons with histopathological changes consistent with granulovacuolar degeneration(GVD) were found in brain sections from aged cynomolgus monkeys (Macacafascicularis) with clinical and pathological signs of cognitive aging. To our knowledge,this is the first reported description of GVD in non-human primates. GVD-like lesionswere found also in age-matched cognitively healthy subjects, albeit in lower numbers,suggesting that they may relate to aging and the increase may have tendency toincrease with the memory deficits. The increased incidence of GVD-like lesions inmemory-impaired subjects with pahological backgrounds of senile plaques (SPs) andtauopathy is, however, an interesting observation of relevance to the characterization ofpathologies in the spontaneous cynomolgus monkey model of human Alzheimer{\textquoteright}s typeof brain pathology.",
keywords = "non-human primate, neurodegenerative disease, Alzheimer's disease, aging, histopathology, spontaneous lessions",
author = "Darusman, {Huda S.} and Agungpriyono, {Dewi Ratih} and Kusumaputri, {Vinka A.} and Dondin Sajuthi and Schapiro, {Steven J.} and Jann Hau",
year = "2019",
month = mar,
day = "7",
doi = "10.3389/fnagi.2019.00050",
language = "English",
volume = "11",
pages = "1--5",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Granulovacuolar Degeneration in Brains of Senile Cynomolgus Monkeys

AU - Darusman, Huda S.

AU - Agungpriyono, Dewi Ratih

AU - Kusumaputri, Vinka A.

AU - Sajuthi, Dondin

AU - Schapiro, Steven J.

AU - Hau, Jann

PY - 2019/3/7

Y1 - 2019/3/7

N2 - Neurons with histopathological changes consistent with granulovacuolar degeneration(GVD) were found in brain sections from aged cynomolgus monkeys (Macacafascicularis) with clinical and pathological signs of cognitive aging. To our knowledge,this is the first reported description of GVD in non-human primates. GVD-like lesionswere found also in age-matched cognitively healthy subjects, albeit in lower numbers,suggesting that they may relate to aging and the increase may have tendency toincrease with the memory deficits. The increased incidence of GVD-like lesions inmemory-impaired subjects with pahological backgrounds of senile plaques (SPs) andtauopathy is, however, an interesting observation of relevance to the characterization ofpathologies in the spontaneous cynomolgus monkey model of human Alzheimer’s typeof brain pathology.

AB - Neurons with histopathological changes consistent with granulovacuolar degeneration(GVD) were found in brain sections from aged cynomolgus monkeys (Macacafascicularis) with clinical and pathological signs of cognitive aging. To our knowledge,this is the first reported description of GVD in non-human primates. GVD-like lesionswere found also in age-matched cognitively healthy subjects, albeit in lower numbers,suggesting that they may relate to aging and the increase may have tendency toincrease with the memory deficits. The increased incidence of GVD-like lesions inmemory-impaired subjects with pahological backgrounds of senile plaques (SPs) andtauopathy is, however, an interesting observation of relevance to the characterization ofpathologies in the spontaneous cynomolgus monkey model of human Alzheimer’s typeof brain pathology.

KW - non-human primate

KW - neurodegenerative disease

KW - Alzheimer's disease

KW - aging

KW - histopathology

KW - spontaneous lessions

U2 - 10.3389/fnagi.2019.00050

DO - 10.3389/fnagi.2019.00050

M3 - Journal article

C2 - 30899220

VL - 11

SP - 1

EP - 5

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

M1 - 50

ER -

ID: 223975829