GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources

Research output: Contribution to journalJournal articleResearchpeer-review


  • Fulltext

    Final published version, 2.97 MB, PDF document

G protein-coupled receptors (GPCRs) are physiologically abundant signaling hubs routing hundreds of extracellular signal substances and drugs into intracellular pathways. The GPCR database, GPCRdb supports >5000 interdisciplinary researchers every month with reference data, analysis, visualization, experiment design and dissemination. Here, we present our fifth major GPCRdb release setting out with an overview of the many resources for receptor sequences, structures, and ligands. This includes recently published additions of class D generic residue numbers, a comparative structure analysis tool to identify functional determinants, trees clustering GPCR structures by 3D conformation, and mutations stabilizing inactive/active states. We provide new state-specific structure models of all human non-olfactory GPCRs built using AlphaFold2-MultiState. We also provide a new resource of endogenous ligands along with a larger number of surrogate ligands with bioactivity, vendor, and physiochemical descriptor data. The one-stop-shop ligand resources integrate ligands/data from the ChEMBL, Guide to Pharmacology, PDSP Ki and PubChem database. The GPCRdb is available at

Original languageEnglish
JournalNucleic Acids Research
Issue numberD1
Pages (from-to)D395–D402
Publication statusPublished - 2023

Number of downloads are based on statistics from Google Scholar and

No data available

ID: 326480689