Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations
Research output: Contribution to journal › Journal article › Research › peer-review
Glucokinase diabetes, also called GCK-MODY or maturity-onset diabetes of the young type 2 (MODY2), is caused by heterozygous mutations in the gene encoding glucokinase (GCK). Objective: The aim of study was to investigate the current prevalence of GCK mutations in a large cohort of Czech patients with typical clinical appearance of GCK-MODY. In addition, we reanalyzed the negative results obtained previously by screening using the denaturing high-performance liquid chromatography (dHPLC).
| Original language | English |
|---|---|
| Journal | Pediatric Diabetes Online |
| Volume | 11 |
| Issue number | 8 |
| Pages (from-to) | 529-35 |
| Number of pages | 7 |
| ISSN | 1399-5448 |
| DOIs | |
| Publication status | Published - 1 Dec 2010 |
- Adolescent, Child, Chromatography, High Pressure Liquid, Czech Republic, Diabetes Mellitus, Type 2, Glucokinase, Humans, Mutation, Prevalence, Protein Denaturation, Young Adult
Research areas
ID: 35312405