Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke. / Lie, Maria E K; Al-Khawaja, Anas; Damgaard, Maria; Haugaard, Anne S; Schousboe, Arne; Clarkson, Andrew N; Wellendorph, Petrine.

Advances in Neurobiology. Vol. 16 2017. p. 137-167 (Advances in Neurobiology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Lie, MEK, Al-Khawaja, A, Damgaard, M, Haugaard, AS, Schousboe, A, Clarkson, AN & Wellendorph, P 2017, Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke. in Advances in Neurobiology. vol. 16, Advances in Neurobiology, pp. 137-167. https://doi.org/10.1007/978-3-319-55769-4_7

APA

Lie, M. E. K., Al-Khawaja, A., Damgaard, M., Haugaard, A. S., Schousboe, A., Clarkson, A. N., & Wellendorph, P. (2017). Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke. In Advances in Neurobiology (Vol. 16, pp. 137-167). Advances in Neurobiology https://doi.org/10.1007/978-3-319-55769-4_7

Vancouver

Lie MEK, Al-Khawaja A, Damgaard M, Haugaard AS, Schousboe A, Clarkson AN et al. Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke. In Advances in Neurobiology. Vol. 16. 2017. p. 137-167. (Advances in Neurobiology). https://doi.org/10.1007/978-3-319-55769-4_7

Author

Lie, Maria E K ; Al-Khawaja, Anas ; Damgaard, Maria ; Haugaard, Anne S ; Schousboe, Arne ; Clarkson, Andrew N ; Wellendorph, Petrine. / Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke. Advances in Neurobiology. Vol. 16 2017. pp. 137-167 (Advances in Neurobiology).

Bibtex

@inbook{a2d44f4b1cb042aea37facb2b98f1eaf,
title = "Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke",
abstract = "Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABAA receptors that sense ambient GABA and mediate a persistent GABAergic conductance. An increase in tonic inhibition may, however, also be obtained indirectly by inhibiting glial GABA transporters (GATs). These are sodium-coupled membrane transport proteins that normally act to terminate GABA neurotransmitter action by taking up GABA into surrounding astrocytes. The aim of the review is to provide an overview of glial GATs in regulating tonic inhibition, especially in epilepsy and stroke. This entails a comprehensive summary of changes known to occur in GAT expression levels and signalling following epileptic and ischemic insults. Further, we discuss the accumulating pharmacological evidence for targeting GATs in these diseases.",
keywords = "Journal Article",
author = "Lie, {Maria E K} and Anas Al-Khawaja and Maria Damgaard and Haugaard, {Anne S} and Arne Schousboe and Clarkson, {Andrew N} and Petrine Wellendorph",
year = "2017",
doi = "10.1007/978-3-319-55769-4_7",
language = "English",
volume = "16",
series = "Advances in Neurobiology",
publisher = "Springer",
pages = "137--167",
booktitle = "Advances in Neurobiology",

}

RIS

TY - CHAP

T1 - Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke

AU - Lie, Maria E K

AU - Al-Khawaja, Anas

AU - Damgaard, Maria

AU - Haugaard, Anne S

AU - Schousboe, Arne

AU - Clarkson, Andrew N

AU - Wellendorph, Petrine

PY - 2017

Y1 - 2017

N2 - Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABAA receptors that sense ambient GABA and mediate a persistent GABAergic conductance. An increase in tonic inhibition may, however, also be obtained indirectly by inhibiting glial GABA transporters (GATs). These are sodium-coupled membrane transport proteins that normally act to terminate GABA neurotransmitter action by taking up GABA into surrounding astrocytes. The aim of the review is to provide an overview of glial GATs in regulating tonic inhibition, especially in epilepsy and stroke. This entails a comprehensive summary of changes known to occur in GAT expression levels and signalling following epileptic and ischemic insults. Further, we discuss the accumulating pharmacological evidence for targeting GATs in these diseases.

AB - Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABAA receptors that sense ambient GABA and mediate a persistent GABAergic conductance. An increase in tonic inhibition may, however, also be obtained indirectly by inhibiting glial GABA transporters (GATs). These are sodium-coupled membrane transport proteins that normally act to terminate GABA neurotransmitter action by taking up GABA into surrounding astrocytes. The aim of the review is to provide an overview of glial GATs in regulating tonic inhibition, especially in epilepsy and stroke. This entails a comprehensive summary of changes known to occur in GAT expression levels and signalling following epileptic and ischemic insults. Further, we discuss the accumulating pharmacological evidence for targeting GATs in these diseases.

KW - Journal Article

U2 - 10.1007/978-3-319-55769-4_7

DO - 10.1007/978-3-319-55769-4_7

M3 - Book chapter

C2 - 28828609

VL - 16

T3 - Advances in Neurobiology

SP - 137

EP - 167

BT - Advances in Neurobiology

ER -

ID: 186088753