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Genomic insights into the Ixodes scapularis tick vector of Lyme disease. / Gulia-Nuss, Monika; Nuss, Andrew B.; Meyer, Jason M.; Sonenshine, Daniel E; Roe, R. Michael; Waterhouse, Robert M.; Sattelle, David B.; de la Fuente, José; Ribeiro, Jose M.; Megy, Karine; Thimmapuram, Jyothi; Miller, Jason R.; Walenz, Brian P.; Koren, Sergey; Hostetler, Jessica B.; Thiagarajan, Mathangi; Joardar, Vinita S.; Hannick, Linda I.; Bidwell, Shelby; Hammond, Martin P; Young, Sarah; Zeng, Qiandong; Abrudan, Jenica L; Almeida, Francisca C; Ayllón, Nieves; Bhide, Ketaki; Bissinger, Brooke W; Bonzon-Kulichenko, Elena; Buckingham, Steven D.; Caffrey, Daniel R.; Caimano, Melissa J.; Croset, Vincent; Driscoll, Timothy; Gilbert, Don; Gillespie, Joseph J.; Giraldo-Calderón, Gloria I; Grabowski, Jeffrey M.; Jiang, David; Khalil, Sayed M. S.; Kim, Donghun; Kocan, Katherine M.; Koči, Juraj; Kuhn, Richard J.; Kurtti, Timothy J.; Lees, Kristin; Lang, Emma G.; Kennedy, Ryan C.; Kwon, Hyeogsun; Perera, Rushika; Qi, Yumin; Radolf, Justin D.; Sakamoto, Joyce M; Sánchez-Gracia, Alejandro; Severo, Maiara S.; Silverman, Neal; Šimo, Ladislav; Tojo, Marta; Tornador, Cristian; Van Zee, Janice P.; Vázquez, Jesús; Garrett Vieira, Filipe Jorge; Villar, Margarita; Wespiser, Adam R.; Yang, Yunlong; Zhu, Jiwei; Arensburger, Peter; Pietrantonio, Patricia V; Barker, Stephen C; Shao, Renfu; Zdobnov, Evgeny M.; Hauser, Frank; Grimmelikhuijzen, Cornelis (Cok); Park, Yoonseong; Rozas, Julio; Benton, Richard; Pedra, Joao H. F.; Nelson, David R; Unger, Maria F.; Tubio, Jose M C; Tu, Zhijian; Robertson, Hugh M.; Shumway, Martin; Sutton, Granger; Wortman, Jennifer R.; Lawson, Daniel; Wikel, Stephen K.; Nene, Vishvanath M.; Fraser, Claire M.; Collins, Frank H.; Birren, Bruce; Nelson, Karen E.; Caler, Elisabet; Hill, Catherine A.
In:
Nature Communications, Vol. 7, 10507, 2016.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Gulia-Nuss, M, Nuss, AB, Meyer, JM, Sonenshine, DE, Roe, RM, Waterhouse, RM, Sattelle, DB, de la Fuente, J, Ribeiro, JM, Megy, K, Thimmapuram, J, Miller, JR, Walenz, BP, Koren, S, Hostetler, JB, Thiagarajan, M, Joardar, VS, Hannick, LI, Bidwell, S, Hammond, MP, Young, S, Zeng, Q, Abrudan, JL, Almeida, FC, Ayllón, N, Bhide, K, Bissinger, BW, Bonzon-Kulichenko, E, Buckingham, SD, Caffrey, DR, Caimano, MJ, Croset, V, Driscoll, T, Gilbert, D, Gillespie, JJ, Giraldo-Calderón, GI, Grabowski, JM, Jiang, D, Khalil, SMS, Kim, D, Kocan, KM, Koči, J, Kuhn, RJ, Kurtti, TJ, Lees, K, Lang, EG, Kennedy, RC, Kwon, H, Perera, R, Qi, Y, Radolf, JD, Sakamoto, JM, Sánchez-Gracia, A, Severo, MS, Silverman, N, Šimo, L, Tojo, M, Tornador, C, Van Zee, JP, Vázquez, J
, Garrett Vieira, FJ, Villar, M, Wespiser, AR, Yang, Y, Zhu, J, Arensburger, P, Pietrantonio, PV, Barker, SC, Shao, R, Zdobnov, EM
, Hauser, F, Grimmelikhuijzen, CC, Park, Y, Rozas, J, Benton, R, Pedra, JHF, Nelson, DR, Unger, MF, Tubio, JMC, Tu, Z, Robertson, HM, Shumway, M, Sutton, G, Wortman, JR, Lawson, D, Wikel, SK, Nene, VM, Fraser, CM, Collins, FH, Birren, B, Nelson, KE, Caler, E & Hill, CA 2016, '
Genomic insights into the Ixodes scapularis tick vector of Lyme disease',
Nature Communications, vol. 7, 10507.
https://doi.org/10.1038/ncomms10507APA
Gulia-Nuss, M., Nuss, A. B., Meyer, J. M., Sonenshine, D. E., Roe, R. M., Waterhouse, R. M., Sattelle, D. B., de la Fuente, J., Ribeiro, J. M., Megy, K., Thimmapuram, J., Miller, J. R., Walenz, B. P., Koren, S., Hostetler, J. B., Thiagarajan, M., Joardar, V. S., Hannick, L. I., Bidwell, S., ... Hill, C. A. (2016).
Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
Nature Communications,
7, [10507].
https://doi.org/10.1038/ncomms10507Vancouver
Gulia-Nuss M, Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM et al.
Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
Nature Communications. 2016;7. 10507.
https://doi.org/10.1038/ncomms10507Author
Gulia-Nuss, Monika ; Nuss, Andrew B. ; Meyer, Jason M. ; Sonenshine, Daniel E ; Roe, R. Michael ; Waterhouse, Robert M. ; Sattelle, David B. ; de la Fuente, José ; Ribeiro, Jose M. ; Megy, Karine ; Thimmapuram, Jyothi ; Miller, Jason R. ; Walenz, Brian P. ; Koren, Sergey ; Hostetler, Jessica B. ; Thiagarajan, Mathangi ; Joardar, Vinita S. ; Hannick, Linda I. ; Bidwell, Shelby ; Hammond, Martin P ; Young, Sarah ; Zeng, Qiandong ; Abrudan, Jenica L ; Almeida, Francisca C ; Ayllón, Nieves ; Bhide, Ketaki ; Bissinger, Brooke W ; Bonzon-Kulichenko, Elena ; Buckingham, Steven D. ; Caffrey, Daniel R. ; Caimano, Melissa J. ; Croset, Vincent ; Driscoll, Timothy ; Gilbert, Don ; Gillespie, Joseph J. ; Giraldo-Calderón, Gloria I ; Grabowski, Jeffrey M. ; Jiang, David ; Khalil, Sayed M. S. ; Kim, Donghun ; Kocan, Katherine M. ; Koči, Juraj ; Kuhn, Richard J. ; Kurtti, Timothy J. ; Lees, Kristin ; Lang, Emma G. ; Kennedy, Ryan C. ; Kwon, Hyeogsun ; Perera, Rushika ; Qi, Yumin ; Radolf, Justin D. ; Sakamoto, Joyce M ; Sánchez-Gracia, Alejandro ; Severo, Maiara S. ; Silverman, Neal ; Šimo, Ladislav ; Tojo, Marta ; Tornador, Cristian ; Van Zee, Janice P. ; Vázquez, Jesús ; Garrett Vieira, Filipe Jorge ; Villar, Margarita ; Wespiser, Adam R. ; Yang, Yunlong ; Zhu, Jiwei ; Arensburger, Peter ; Pietrantonio, Patricia V ; Barker, Stephen C ; Shao, Renfu ; Zdobnov, Evgeny M. ; Hauser, Frank ; Grimmelikhuijzen, Cornelis (Cok) ; Park, Yoonseong ; Rozas, Julio ; Benton, Richard ; Pedra, Joao H. F. ; Nelson, David R ; Unger, Maria F. ; Tubio, Jose M C ; Tu, Zhijian ; Robertson, Hugh M. ; Shumway, Martin ; Sutton, Granger ; Wortman, Jennifer R. ; Lawson, Daniel ; Wikel, Stephen K. ; Nene, Vishvanath M. ; Fraser, Claire M. ; Collins, Frank H. ; Birren, Bruce ; Nelson, Karen E. ; Caler, Elisabet ; Hill, Catherine A. / Genomic insights into the Ixodes scapularis tick vector of Lyme disease. In: Nature Communications. 2016 ; Vol. 7.
Bibtex
@article{394a9912d607460a9cc04ddb1551ffb5,
title = "Genomic insights into the Ixodes scapularis tick vector of Lyme disease",
abstract = "Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.",
author = "Monika Gulia-Nuss and Nuss, {Andrew B.} and Meyer, {Jason M.} and Sonenshine, {Daniel E} and Roe, {R. Michael} and Waterhouse, {Robert M.} and Sattelle, {David B.} and {de la Fuente}, Jos{\'e} and Ribeiro, {Jose M.} and Karine Megy and Jyothi Thimmapuram and Miller, {Jason R.} and Walenz, {Brian P.} and Sergey Koren and Hostetler, {Jessica B.} and Mathangi Thiagarajan and Joardar, {Vinita S.} and Hannick, {Linda I.} and Shelby Bidwell and Hammond, {Martin P} and Sarah Young and Qiandong Zeng and Abrudan, {Jenica L} and Almeida, {Francisca C} and Nieves Ayll{\'o}n and Ketaki Bhide and Bissinger, {Brooke W} and Elena Bonzon-Kulichenko and Buckingham, {Steven D.} and Caffrey, {Daniel R.} and Caimano, {Melissa J.} and Vincent Croset and Timothy Driscoll and Don Gilbert and Gillespie, {Joseph J.} and Giraldo-Calder{\'o}n, {Gloria I} and Grabowski, {Jeffrey M.} and David Jiang and Khalil, {Sayed M. S.} and Donghun Kim and Kocan, {Katherine M.} and Juraj Ko{\v c}i and Kuhn, {Richard J.} and Kurtti, {Timothy J.} and Kristin Lees and Lang, {Emma G.} and Kennedy, {Ryan C.} and Hyeogsun Kwon and Rushika Perera and Yumin Qi and Radolf, {Justin D.} and Sakamoto, {Joyce M} and Alejandro S{\'a}nchez-Gracia and Severo, {Maiara S.} and Neal Silverman and Ladislav {\v S}imo and Marta Tojo and Cristian Tornador and {Van Zee}, {Janice P.} and Jes{\'u}s V{\'a}zquez and {Garrett Vieira}, {Filipe Jorge} and Margarita Villar and Wespiser, {Adam R.} and Yunlong Yang and Jiwei Zhu and Peter Arensburger and Pietrantonio, {Patricia V} and Barker, {Stephen C} and Renfu Shao and Zdobnov, {Evgeny M.} and Frank Hauser and Grimmelikhuijzen, {Cornelis (Cok)} and Yoonseong Park and Julio Rozas and Richard Benton and Pedra, {Joao H. F.} and Nelson, {David R} and Unger, {Maria F.} and Tubio, {Jose M C} and Zhijian Tu and Robertson, {Hugh M.} and Martin Shumway and Granger Sutton and Wortman, {Jennifer R.} and Daniel Lawson and Wikel, {Stephen K.} and Nene, {Vishvanath M.} and Fraser, {Claire M.} and Collins, {Frank H.} and Bruce Birren and Nelson, {Karen E.} and Elisabet Caler and Hill, {Catherine A.}",
year = "2016",
doi = "10.1038/ncomms10507",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Genomic insights into the Ixodes scapularis tick vector of Lyme disease
AU - Gulia-Nuss, Monika
AU - Nuss, Andrew B.
AU - Meyer, Jason M.
AU - Sonenshine, Daniel E
AU - Roe, R. Michael
AU - Waterhouse, Robert M.
AU - Sattelle, David B.
AU - de la Fuente, José
AU - Ribeiro, Jose M.
AU - Megy, Karine
AU - Thimmapuram, Jyothi
AU - Miller, Jason R.
AU - Walenz, Brian P.
AU - Koren, Sergey
AU - Hostetler, Jessica B.
AU - Thiagarajan, Mathangi
AU - Joardar, Vinita S.
AU - Hannick, Linda I.
AU - Bidwell, Shelby
AU - Hammond, Martin P
AU - Young, Sarah
AU - Zeng, Qiandong
AU - Abrudan, Jenica L
AU - Almeida, Francisca C
AU - Ayllón, Nieves
AU - Bhide, Ketaki
AU - Bissinger, Brooke W
AU - Bonzon-Kulichenko, Elena
AU - Buckingham, Steven D.
AU - Caffrey, Daniel R.
AU - Caimano, Melissa J.
AU - Croset, Vincent
AU - Driscoll, Timothy
AU - Gilbert, Don
AU - Gillespie, Joseph J.
AU - Giraldo-Calderón, Gloria I
AU - Grabowski, Jeffrey M.
AU - Jiang, David
AU - Khalil, Sayed M. S.
AU - Kim, Donghun
AU - Kocan, Katherine M.
AU - Koči, Juraj
AU - Kuhn, Richard J.
AU - Kurtti, Timothy J.
AU - Lees, Kristin
AU - Lang, Emma G.
AU - Kennedy, Ryan C.
AU - Kwon, Hyeogsun
AU - Perera, Rushika
AU - Qi, Yumin
AU - Radolf, Justin D.
AU - Sakamoto, Joyce M
AU - Sánchez-Gracia, Alejandro
AU - Severo, Maiara S.
AU - Silverman, Neal
AU - Šimo, Ladislav
AU - Tojo, Marta
AU - Tornador, Cristian
AU - Van Zee, Janice P.
AU - Vázquez, Jesús
AU - Garrett Vieira, Filipe Jorge
AU - Villar, Margarita
AU - Wespiser, Adam R.
AU - Yang, Yunlong
AU - Zhu, Jiwei
AU - Arensburger, Peter
AU - Pietrantonio, Patricia V
AU - Barker, Stephen C
AU - Shao, Renfu
AU - Zdobnov, Evgeny M.
AU - Hauser, Frank
AU - Grimmelikhuijzen, Cornelis (Cok)
AU - Park, Yoonseong
AU - Rozas, Julio
AU - Benton, Richard
AU - Pedra, Joao H. F.
AU - Nelson, David R
AU - Unger, Maria F.
AU - Tubio, Jose M C
AU - Tu, Zhijian
AU - Robertson, Hugh M.
AU - Shumway, Martin
AU - Sutton, Granger
AU - Wortman, Jennifer R.
AU - Lawson, Daniel
AU - Wikel, Stephen K.
AU - Nene, Vishvanath M.
AU - Fraser, Claire M.
AU - Collins, Frank H.
AU - Birren, Bruce
AU - Nelson, Karen E.
AU - Caler, Elisabet
AU - Hill, Catherine A.
PY - 2016
Y1 - 2016
N2 - Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
AB - Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
U2 - 10.1038/ncomms10507
DO - 10.1038/ncomms10507
M3 - Journal article
C2 - 26856261
VL - 7
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 10507
ER -
