Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. / Asmar, Fazila; Punj, Vasu; Christensen, Jesper Aagaard; Pedersen, Marianne T; Pedersen, Anja; Nielsen, Anders B; Hother, Christoffer; Ralfkiaer, Ulrik; Brown, Peter; Ralfkiaer, Elisabeth; Helin, Kristian; Grønbæk, Kirsten.

In: Haematologica, Vol. 98, No. 12, 12.2013, p. 1912-20.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Asmar, F, Punj, V, Christensen, JA, Pedersen, MT, Pedersen, A, Nielsen, AB, Hother, C, Ralfkiaer, U, Brown, P, Ralfkiaer, E, Helin, K & Grønbæk, K 2013, 'Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma', Haematologica, vol. 98, no. 12, pp. 1912-20. https://doi.org/10.3324/haematol.2013.088740

APA

Asmar, F., Punj, V., Christensen, J. A., Pedersen, M. T., Pedersen, A., Nielsen, A. B., Hother, C., Ralfkiaer, U., Brown, P., Ralfkiaer, E., Helin, K., & Grønbæk, K. (2013). Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica, 98(12), 1912-20. https://doi.org/10.3324/haematol.2013.088740

Vancouver

Asmar F, Punj V, Christensen JA, Pedersen MT, Pedersen A, Nielsen AB et al. Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica. 2013 Dec;98(12):1912-20. https://doi.org/10.3324/haematol.2013.088740

Author

Asmar, Fazila ; Punj, Vasu ; Christensen, Jesper Aagaard ; Pedersen, Marianne T ; Pedersen, Anja ; Nielsen, Anders B ; Hother, Christoffer ; Ralfkiaer, Ulrik ; Brown, Peter ; Ralfkiaer, Elisabeth ; Helin, Kristian ; Grønbæk, Kirsten. / Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. In: Haematologica. 2013 ; Vol. 98, No. 12. pp. 1912-20.

Bibtex

@article{dc41b40427bc46dc85249cdd2fd7fecf,
title = "Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma",
abstract = "The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. However, the detection rates and the types of TET2 mutations vary, and the relation to global methylation patterns has not been investigated. Here, we show TET2 mutations in 12 of 100 diffuse large B-cell lymphomas with 7% carrying loss-of-function and 5% carrying missense mutations. Genome-wide methylation profiling using 450K Illumina arrays identified 315 differentially methylated genes between TET2 mutated and TET2 wild-type cases. TET2 mutations are primarily associated with hypermethylation within CpG islands (70%; P",
author = "Fazila Asmar and Vasu Punj and Christensen, {Jesper Aagaard} and Pedersen, {Marianne T} and Anja Pedersen and Nielsen, {Anders B} and Christoffer Hother and Ulrik Ralfkiaer and Peter Brown and Elisabeth Ralfkiaer and Kristian Helin and Kirsten Gr{\o}nb{\ae}k",
year = "2013",
month = dec,
doi = "10.3324/haematol.2013.088740",
language = "English",
volume = "98",
pages = "1912--20",
journal = "Haematologica",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "12",

}

RIS

TY - JOUR

T1 - Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

AU - Asmar, Fazila

AU - Punj, Vasu

AU - Christensen, Jesper Aagaard

AU - Pedersen, Marianne T

AU - Pedersen, Anja

AU - Nielsen, Anders B

AU - Hother, Christoffer

AU - Ralfkiaer, Ulrik

AU - Brown, Peter

AU - Ralfkiaer, Elisabeth

AU - Helin, Kristian

AU - Grønbæk, Kirsten

PY - 2013/12

Y1 - 2013/12

N2 - The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. However, the detection rates and the types of TET2 mutations vary, and the relation to global methylation patterns has not been investigated. Here, we show TET2 mutations in 12 of 100 diffuse large B-cell lymphomas with 7% carrying loss-of-function and 5% carrying missense mutations. Genome-wide methylation profiling using 450K Illumina arrays identified 315 differentially methylated genes between TET2 mutated and TET2 wild-type cases. TET2 mutations are primarily associated with hypermethylation within CpG islands (70%; P

AB - The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. However, the detection rates and the types of TET2 mutations vary, and the relation to global methylation patterns has not been investigated. Here, we show TET2 mutations in 12 of 100 diffuse large B-cell lymphomas with 7% carrying loss-of-function and 5% carrying missense mutations. Genome-wide methylation profiling using 450K Illumina arrays identified 315 differentially methylated genes between TET2 mutated and TET2 wild-type cases. TET2 mutations are primarily associated with hypermethylation within CpG islands (70%; P

U2 - 10.3324/haematol.2013.088740

DO - 10.3324/haematol.2013.088740

M3 - Journal article

C2 - 23831920

VL - 98

SP - 1912

EP - 1920

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 12

ER -

ID: 94410503