Genome-wide association study of prostate cancer-specific survival
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.
METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).
RESULTS: We observed no significant association between genetic variants and prostate cancer survival.
CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study.
IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.
| Original language | English |
|---|---|
| Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| Volume | 24 |
| Issue number | 11 |
| Pages (from-to) | 1796-1800 |
| Number of pages | 5 |
| ISSN | 1055-9965 |
| DOIs | |
| Publication status | Published - Nov 2015 |
ID: 162641906