Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers
Research output: Contribution to journal › Journal article › Research › peer-review
Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A genome-wide association study recently identified an association between the rare allele of the single-nucleotide polymorphism (SNP) rs3814113 (ie, the C allele) at 9p22.2 and decreased risk of ovarian cancer for women in the general population. We evaluated the association of this SNP with ovarian cancer risk among BRCA1 or BRCA2 mutation carriers by use of data from the Consortium of Investigators of Modifiers of BRCA1/2.
Original language | English |
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Journal | National Cancer Institute. Journal (Print) |
Volume | 103 |
Issue number | 2 |
Pages (from-to) | 105-16 |
Number of pages | 12 |
ISSN | 0027-8874 |
DOIs | |
Publication status | Published - 2011 |
ID: 40153980