Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers

Research output: Contribution to journalJournal articlepeer-review

  • Susan J Ramus
  • Christiana Kartsonaki
  • Simon A Gayther
  • Paul D P Pharoah
  • Olga M Sinilnikova
  • Jonathan Beesley
  • Xiaoqing Chen
  • Lesley McGuffog
  • Sue Healey
  • Fergus J Couch
  • Xianshu Wang
  • Zachary Fredericksen
  • Paolo Peterlongo
  • Siranoush Manoukian
  • Bernard Peissel
  • Daniela Zaffaroni
  • Gaia Roversi
  • Monica Barile
  • Alessandra Viel
  • Anna Allavena
  • Laura Ottini
  • Laura Papi
  • Viviana Gismondi
  • Fabio Capra
  • Paolo Radice
  • Mark H Greene
  • Phuong L Mai
  • Irene L Andrulis
  • Gord Glendon
  • Hilmi Ozcelik
  • Mads Thomassen
  • Gerdes, Anne-Marie Axø
  • Torben A Kruse
  • Dorthe Cruger
  • Uffe Birk Jensen
  • Maria Adelaide Caligo
  • Håkan Olsson
  • Ulf Kristoffersson
  • Annika Lindblom
  • Brita Arver
  • Per W. Karlsson
  • Marie Stenmark Askmalm
  • Ake Borg
  • Susan L Neuhausen
  • Yuan Chun Ding
  • Katherine L Nathanson
  • Susan M Domchek
  • Hansen, Thomas van Overeem
  • Lars Jønson
  • Ejlertsen, Bent Laursen
  • OCGN
Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A genome-wide association study recently identified an association between the rare allele of the single-nucleotide polymorphism (SNP) rs3814113 (ie, the C allele) at 9p22.2 and decreased risk of ovarian cancer for women in the general population. We evaluated the association of this SNP with ovarian cancer risk among BRCA1 or BRCA2 mutation carriers by use of data from the Consortium of Investigators of Modifiers of BRCA1/2.
Original languageEnglish
JournalNational Cancer Institute. Journal (Print)
Issue number2
Pages (from-to)105-16
Number of pages12
Publication statusPublished - 2011

ID: 40153980