Genetic mapping of etiologic brain cell types for obesity
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Genetic mapping of etiologic brain cell types for obesity. / Timshel, Pascal N.; Thompson, Jonatan J.; Pers, Tune H.
In: eLife, Vol. 9, 55851, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic mapping of etiologic brain cell types for obesity
AU - Timshel, Pascal N.
AU - Thompson, Jonatan J.
AU - Pers, Tune H.
PY - 2020
Y1 - 2020
N2 - The underlying cell types mediating predisposition to obesity remain largely obscure. Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index (BMI) genome-wide association study (GWAS) data from >457,000 individuals. Developing a novel strategy for integrating scRNA-seq data with GWAS data, we identified 26, exclusively neuronal, cell types from the hypothalamus, subthalamus, midbrain, hippocampus, thalamus, cortex, pons, medulla, pallidum that were significantly enriched for BMI heritability (p
AB - The underlying cell types mediating predisposition to obesity remain largely obscure. Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index (BMI) genome-wide association study (GWAS) data from >457,000 individuals. Developing a novel strategy for integrating scRNA-seq data with GWAS data, we identified 26, exclusively neuronal, cell types from the hypothalamus, subthalamus, midbrain, hippocampus, thalamus, cortex, pons, medulla, pallidum that were significantly enriched for BMI heritability (p
KW - GENOME-WIDE ASSOCIATION
KW - BODY-MASS INDEX
KW - PARTITIONING HERITABILITY
KW - ENERGY-BALANCE
KW - FOOD-INTAKE
KW - EXPRESSION
KW - VARIANTS
KW - CIRCUIT
KW - MOUSE
KW - COMMON
U2 - 10.7554/eLife.55851
DO - 10.7554/eLife.55851
M3 - Journal article
C2 - 32955435
VL - 9
JO - eLife
JF - eLife
SN - 2050-084X
M1 - 55851
ER -
ID: 249944656