Genetic effects on the timing of parturition and links to fetal birth weight: [Inkl. Correction]

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genetic effects on the timing of parturition and links to fetal birth weight : [Inkl. Correction]. / Solé-Navais, Pol; Flatley, Christopher; Steinthorsdottir, Valgerdur; Vaudel, Marc; Juodakis, Julius; Chen, Jing; Laisk, Triin; LaBella, Abigail L.; Westergaard, David; Bacelis, Jonas; Brumpton, Ben; Skotte, Line; Borges, Maria C.; Helgeland, Øyvind; Mahajan, Anubha; Wielscher, Matthias; Lin, Frederick; Briggs, Catherine; Wang, Carol A.; Moen, Gunn Helen; Beaumont, Robin N.; Bradfield, Jonathan P.; Abraham, Abin; Thorleifsson, Gudmar; Gabrielsen, Maiken E.; Ostrowski, Sisse R.; Modzelewska, Dominika; Nohr, Ellen A.; Hypponen, Elina; Srivastava, Amit; Talbot, Octavious; Allard, Catherine; Williams, Scott M.; Menon, Ramkumar; Shields, Beverley M.; Sveinbjornsson, Gardar; Xu, Huan; Melbye, Mads; Lowe, William; Bouchard, Luigi; Oken, Emily; Pedersen, Ole B.; Gudbjartsson, Daniel F.; Erikstrup, Christian; Sørensen, Erik; McCarthy, Mark I.; Lie, Rolv T.; Ullum, Henrik; Nyegaard, Mette; Nielsen, Henriette S.; Early Growth Genetics Consortium; Estonian Biobank Research Team; Danish Blood Donor Study Genomic Consortium.

In: Nature Genetics, Vol. 55, 2023, p. 559–567.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Solé-Navais, P, Flatley, C, Steinthorsdottir, V, Vaudel, M, Juodakis, J, Chen, J, Laisk, T, LaBella, AL, Westergaard, D, Bacelis, J, Brumpton, B, Skotte, L, Borges, MC, Helgeland, Ø, Mahajan, A, Wielscher, M, Lin, F, Briggs, C, Wang, CA, Moen, GH, Beaumont, RN, Bradfield, JP, Abraham, A, Thorleifsson, G, Gabrielsen, ME, Ostrowski, SR, Modzelewska, D, Nohr, EA, Hypponen, E, Srivastava, A, Talbot, O, Allard, C, Williams, SM, Menon, R, Shields, BM, Sveinbjornsson, G, Xu, H, Melbye, M, Lowe, W, Bouchard, L, Oken, E, Pedersen, OB, Gudbjartsson, DF, Erikstrup, C, Sørensen, E, McCarthy, MI, Lie, RT, Ullum, H, Nyegaard, M, Nielsen, HS, Early Growth Genetics Consortium, Estonian Biobank Research Team & Danish Blood Donor Study Genomic Consortium 2023, 'Genetic effects on the timing of parturition and links to fetal birth weight: [Inkl. Correction]', Nature Genetics, vol. 55, pp. 559–567. https://doi.org/10.1038/s41588-023-01343-9

APA

Solé-Navais, P., Flatley, C., Steinthorsdottir, V., Vaudel, M., Juodakis, J., Chen, J., Laisk, T., LaBella, A. L., Westergaard, D., Bacelis, J., Brumpton, B., Skotte, L., Borges, M. C., Helgeland, Ø., Mahajan, A., Wielscher, M., Lin, F., Briggs, C., Wang, C. A., ... Danish Blood Donor Study Genomic Consortium (2023). Genetic effects on the timing of parturition and links to fetal birth weight: [Inkl. Correction]. Nature Genetics, 55, 559–567. https://doi.org/10.1038/s41588-023-01343-9

Vancouver

Solé-Navais P, Flatley C, Steinthorsdottir V, Vaudel M, Juodakis J, Chen J et al. Genetic effects on the timing of parturition and links to fetal birth weight: [Inkl. Correction]. Nature Genetics. 2023;55:559–567. https://doi.org/10.1038/s41588-023-01343-9

Author

Solé-Navais, Pol ; Flatley, Christopher ; Steinthorsdottir, Valgerdur ; Vaudel, Marc ; Juodakis, Julius ; Chen, Jing ; Laisk, Triin ; LaBella, Abigail L. ; Westergaard, David ; Bacelis, Jonas ; Brumpton, Ben ; Skotte, Line ; Borges, Maria C. ; Helgeland, Øyvind ; Mahajan, Anubha ; Wielscher, Matthias ; Lin, Frederick ; Briggs, Catherine ; Wang, Carol A. ; Moen, Gunn Helen ; Beaumont, Robin N. ; Bradfield, Jonathan P. ; Abraham, Abin ; Thorleifsson, Gudmar ; Gabrielsen, Maiken E. ; Ostrowski, Sisse R. ; Modzelewska, Dominika ; Nohr, Ellen A. ; Hypponen, Elina ; Srivastava, Amit ; Talbot, Octavious ; Allard, Catherine ; Williams, Scott M. ; Menon, Ramkumar ; Shields, Beverley M. ; Sveinbjornsson, Gardar ; Xu, Huan ; Melbye, Mads ; Lowe, William ; Bouchard, Luigi ; Oken, Emily ; Pedersen, Ole B. ; Gudbjartsson, Daniel F. ; Erikstrup, Christian ; Sørensen, Erik ; McCarthy, Mark I. ; Lie, Rolv T. ; Ullum, Henrik ; Nyegaard, Mette ; Nielsen, Henriette S. ; Early Growth Genetics Consortium ; Estonian Biobank Research Team ; Danish Blood Donor Study Genomic Consortium. / Genetic effects on the timing of parturition and links to fetal birth weight : [Inkl. Correction]. In: Nature Genetics. 2023 ; Vol. 55. pp. 559–567.

Bibtex

@article{08d5bce1ae124a45b894fad81508795c,
title = "Genetic effects on the timing of parturition and links to fetal birth weight: [Inkl. Correction]",
abstract = "The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analysis of the parental transmitted and nontransmitted alleles (n = 136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, whereas 7 act both through the maternal and fetal genomes and 2 act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight. The present study provides insights into the genetic effects on the timing of parturition and the complex maternal–fetal relationship between gestational duration and birth weight.",
author = "Pol Sol{\'e}-Navais and Christopher Flatley and Valgerdur Steinthorsdottir and Marc Vaudel and Julius Juodakis and Jing Chen and Triin Laisk and LaBella, {Abigail L.} and David Westergaard and Jonas Bacelis and Ben Brumpton and Line Skotte and Borges, {Maria C.} and {\O}yvind Helgeland and Anubha Mahajan and Matthias Wielscher and Frederick Lin and Catherine Briggs and Wang, {Carol A.} and Moen, {Gunn Helen} and Beaumont, {Robin N.} and Bradfield, {Jonathan P.} and Abin Abraham and Gudmar Thorleifsson and Gabrielsen, {Maiken E.} and Ostrowski, {Sisse R.} and Dominika Modzelewska and Nohr, {Ellen A.} and Elina Hypponen and Amit Srivastava and Octavious Talbot and Catherine Allard and Williams, {Scott M.} and Ramkumar Menon and Shields, {Beverley M.} and Gardar Sveinbjornsson and Huan Xu and Mads Melbye and William Lowe and Luigi Bouchard and Emily Oken and Pedersen, {Ole B.} and Gudbjartsson, {Daniel F.} and Christian Erikstrup and Erik S{\o}rensen and McCarthy, {Mark I.} and Lie, {Rolv T.} and Henrik Ullum and Mette Nyegaard and Nielsen, {Henriette S.} and {Early Growth Genetics Consortium} and {Estonian Biobank Research Team} and {Danish Blood Donor Study Genomic Consortium}",
note = "Correction: 10.1038/s41588-023-01412-z Link: https://www.nature.com/articles/s41588-023-01412-z Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s41588-023-01343-9",
language = "English",
volume = "55",
pages = "559–567",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genetic effects on the timing of parturition and links to fetal birth weight

T2 - [Inkl. Correction]

AU - Solé-Navais, Pol

AU - Flatley, Christopher

AU - Steinthorsdottir, Valgerdur

AU - Vaudel, Marc

AU - Juodakis, Julius

AU - Chen, Jing

AU - Laisk, Triin

AU - LaBella, Abigail L.

AU - Westergaard, David

AU - Bacelis, Jonas

AU - Brumpton, Ben

AU - Skotte, Line

AU - Borges, Maria C.

AU - Helgeland, Øyvind

AU - Mahajan, Anubha

AU - Wielscher, Matthias

AU - Lin, Frederick

AU - Briggs, Catherine

AU - Wang, Carol A.

AU - Moen, Gunn Helen

AU - Beaumont, Robin N.

AU - Bradfield, Jonathan P.

AU - Abraham, Abin

AU - Thorleifsson, Gudmar

AU - Gabrielsen, Maiken E.

AU - Ostrowski, Sisse R.

AU - Modzelewska, Dominika

AU - Nohr, Ellen A.

AU - Hypponen, Elina

AU - Srivastava, Amit

AU - Talbot, Octavious

AU - Allard, Catherine

AU - Williams, Scott M.

AU - Menon, Ramkumar

AU - Shields, Beverley M.

AU - Sveinbjornsson, Gardar

AU - Xu, Huan

AU - Melbye, Mads

AU - Lowe, William

AU - Bouchard, Luigi

AU - Oken, Emily

AU - Pedersen, Ole B.

AU - Gudbjartsson, Daniel F.

AU - Erikstrup, Christian

AU - Sørensen, Erik

AU - McCarthy, Mark I.

AU - Lie, Rolv T.

AU - Ullum, Henrik

AU - Nyegaard, Mette

AU - Nielsen, Henriette S.

AU - Early Growth Genetics Consortium

AU - Estonian Biobank Research Team

AU - Danish Blood Donor Study Genomic Consortium

N1 - Correction: 10.1038/s41588-023-01412-z Link: https://www.nature.com/articles/s41588-023-01412-z Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analysis of the parental transmitted and nontransmitted alleles (n = 136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, whereas 7 act both through the maternal and fetal genomes and 2 act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight. The present study provides insights into the genetic effects on the timing of parturition and the complex maternal–fetal relationship between gestational duration and birth weight.

AB - The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analysis of the parental transmitted and nontransmitted alleles (n = 136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, whereas 7 act both through the maternal and fetal genomes and 2 act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight. The present study provides insights into the genetic effects on the timing of parturition and the complex maternal–fetal relationship between gestational duration and birth weight.

U2 - 10.1038/s41588-023-01343-9

DO - 10.1038/s41588-023-01343-9

M3 - Journal article

C2 - 37012456

AN - SCOPUS:85151699870

VL - 55

SP - 559

EP - 567

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -

ID: 344431021