FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
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FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. / von Holstein-Rathlou, Stephanie; BonDurant, Lucas D; Peltekian, Lila; Naber, Meghan C; Yin, Terry C; Claflin, Kristin E; Urizar, Adriana Ibarra; Madsen, Andreas N; Ratner, Cecilia; Holst, Birgitte; Karstoft, Kristian; Vandenbeuch, Aurelie; Anderson, Catherine B; Cassell, Martin D; Thompson, Anthony P; Solomon, Thomas P; Rahmouni, Kamal; Kinnamon, Sue C; Pieper, Andrew A; Gillum, Matthew P; Potthoff, Matthew J.
In: Cell Metabolism, Vol. 23, No. 2, 09.02.2016, p. 335-43.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
AU - von Holstein-Rathlou, Stephanie
AU - BonDurant, Lucas D
AU - Peltekian, Lila
AU - Naber, Meghan C
AU - Yin, Terry C
AU - Claflin, Kristin E
AU - Urizar, Adriana Ibarra
AU - Madsen, Andreas N
AU - Ratner, Cecilia
AU - Holst, Birgitte
AU - Karstoft, Kristian
AU - Vandenbeuch, Aurelie
AU - Anderson, Catherine B
AU - Cassell, Martin D
AU - Thompson, Anthony P
AU - Solomon, Thomas P
AU - Rahmouni, Kamal
AU - Kinnamon, Sue C
AU - Pieper, Andrew A
AU - Gillum, Matthew P
AU - Potthoff, Matthew J
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016/2/9
Y1 - 2016/2/9
N2 - The liver is an important integrator of nutrient metabolism, yet no liver-derived factors regulating nutrient preference or carbohydrate appetite have been identified. Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids. Genetic loss of FGF21 in mice increases sucrose consumption, whereas acute administration or overexpression of FGF21 suppresses the intake of both sugar and non-caloric sweeteners. FGF21 does not affect chorda tympani nerve responses to sweet tastants, instead reducing sweet-seeking behavior and meal size via neurons in the hypothalamus. This liver-to-brain hormonal axis likely represents a negative feedback loop as hepatic FGF21 production is elevated by sucrose ingestion. We conclude that the liver functions to regulate macronutrient-specific intake by producing an endocrine satiety signal that acts centrally to suppress the intake of "sweets."
AB - The liver is an important integrator of nutrient metabolism, yet no liver-derived factors regulating nutrient preference or carbohydrate appetite have been identified. Here we show that the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids. Genetic loss of FGF21 in mice increases sucrose consumption, whereas acute administration or overexpression of FGF21 suppresses the intake of both sugar and non-caloric sweeteners. FGF21 does not affect chorda tympani nerve responses to sweet tastants, instead reducing sweet-seeking behavior and meal size via neurons in the hypothalamus. This liver-to-brain hormonal axis likely represents a negative feedback loop as hepatic FGF21 production is elevated by sucrose ingestion. We conclude that the liver functions to regulate macronutrient-specific intake by producing an endocrine satiety signal that acts centrally to suppress the intake of "sweets."
U2 - 10.1016/j.cmet.2015.12.003
DO - 10.1016/j.cmet.2015.12.003
M3 - Journal article
C2 - 26724858
VL - 23
SP - 335
EP - 343
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 2
ER -
ID: 156086200