Ex vivo intestinal adhesion of Escherichia coli LF82 in Crohn's disease
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Ex vivo intestinal adhesion of Escherichia coli LF82 in Crohn's disease. / Jensen, Stina Rikke; Fink, Lisbeth Nielsen; Nielsen, Ole Haagen; Brynskov, Jørn; Brix, Susanne.
In: Microbial Pathogenesis, Vol. 51, No. 6, 2011, p. 426-31.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Ex vivo intestinal adhesion of Escherichia coli LF82 in Crohn's disease
AU - Jensen, Stina Rikke
AU - Fink, Lisbeth Nielsen
AU - Nielsen, Ole Haagen
AU - Brynskov, Jørn
AU - Brix, Susanne
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Adherent-invasive Escherichia coli (AIEC) are reported to inhabit the gut mucosa in Crohn's disease (CD), however, little is known about the importance of host factors for the interplay between AIEC and the human gut. To examine if differences in bacterial adhesion patterns are disease associated, the AIEC-prototype strain LF82 was evaluated for its ability to adhere to ileal and colonic biopsies from CD and healthy controls (HC). Moreover, the efficacy of the non-pathogenic E. coli Nissle 1917 (ECN) in averting LF82 adhesion to ileal mucosa was assessed. Similar numbers of LF82 adhered to biopsies from CD and HC. A significantly greater LF82 attachment to ileal versus colonic mucosa was found in HC (P
AB - Adherent-invasive Escherichia coli (AIEC) are reported to inhabit the gut mucosa in Crohn's disease (CD), however, little is known about the importance of host factors for the interplay between AIEC and the human gut. To examine if differences in bacterial adhesion patterns are disease associated, the AIEC-prototype strain LF82 was evaluated for its ability to adhere to ileal and colonic biopsies from CD and healthy controls (HC). Moreover, the efficacy of the non-pathogenic E. coli Nissle 1917 (ECN) in averting LF82 adhesion to ileal mucosa was assessed. Similar numbers of LF82 adhered to biopsies from CD and HC. A significantly greater LF82 attachment to ileal versus colonic mucosa was found in HC (P
U2 - http://dx.doi.org/10.1016/j.micpath.2011.08.006
DO - http://dx.doi.org/10.1016/j.micpath.2011.08.006
M3 - Journal article
VL - 51
SP - 426
EP - 431
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
SN - 0882-4010
IS - 6
ER -
ID: 40182475