Experimental headache in humans

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Experimental headache in humans. / Iversen, Helle Klingenberg.

In: Cephalalgia : an international journal of headache, Vol. 15, No. 4, 1995, p. 281-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Iversen, HK 1995, 'Experimental headache in humans', Cephalalgia : an international journal of headache, vol. 15, no. 4, pp. 281-7.

APA

Iversen, H. K. (1995). Experimental headache in humans. Cephalalgia : an international journal of headache, 15(4), 281-7.

Vancouver

Iversen HK. Experimental headache in humans. Cephalalgia : an international journal of headache. 1995;15(4):281-7.

Author

Iversen, Helle Klingenberg. / Experimental headache in humans. In: Cephalalgia : an international journal of headache. 1995 ; Vol. 15, No. 4. pp. 281-7.

Bibtex

@article{e7a8462f93f54deabcba20748b9e64e5,
title = "Experimental headache in humans",
abstract = "The need for valid human experimental models of headache is obvious. Several compounds have been proposed as headache-inducing agents, but only the nitroglycerin (NTG) model has been validated. In healthy subjects, intravenous infusions of the nitric oxide (NO) donor NTG induce a dose-dependent headache and dilatation of the temporal, radial and middle cerebral artery. NTG-induced headache, although less intense, resembles migraine in pain characteristics, but the accompanying symptoms are rarely present. Cephalic large arteries are dilated during migraine headache as well as during NTG headache. N-acetylcysteine enhances the formation of NO and potentiates NTG-induced headache, whereas mepyramine, a H1-antagonist capable of blocking histamine-induced headache, has no effect. Thus, the headache is dependent on NO or other steps in the NO cascade. The model is useful for pharmacological interventions and sumatriptan reduced the NTG-induced headache. The NTG model may be a valuable tool in the development of future migraine drugs.",
keywords = "Cerebrovascular Circulation, Dose-Response Relationship, Drug, Headache, Hemodynamics, Humans, Models, Neurological, Nitroglycerin",
author = "Iversen, {Helle Klingenberg}",
year = "1995",
language = "English",
volume = "15",
pages = "281--7",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Experimental headache in humans

AU - Iversen, Helle Klingenberg

PY - 1995

Y1 - 1995

N2 - The need for valid human experimental models of headache is obvious. Several compounds have been proposed as headache-inducing agents, but only the nitroglycerin (NTG) model has been validated. In healthy subjects, intravenous infusions of the nitric oxide (NO) donor NTG induce a dose-dependent headache and dilatation of the temporal, radial and middle cerebral artery. NTG-induced headache, although less intense, resembles migraine in pain characteristics, but the accompanying symptoms are rarely present. Cephalic large arteries are dilated during migraine headache as well as during NTG headache. N-acetylcysteine enhances the formation of NO and potentiates NTG-induced headache, whereas mepyramine, a H1-antagonist capable of blocking histamine-induced headache, has no effect. Thus, the headache is dependent on NO or other steps in the NO cascade. The model is useful for pharmacological interventions and sumatriptan reduced the NTG-induced headache. The NTG model may be a valuable tool in the development of future migraine drugs.

AB - The need for valid human experimental models of headache is obvious. Several compounds have been proposed as headache-inducing agents, but only the nitroglycerin (NTG) model has been validated. In healthy subjects, intravenous infusions of the nitric oxide (NO) donor NTG induce a dose-dependent headache and dilatation of the temporal, radial and middle cerebral artery. NTG-induced headache, although less intense, resembles migraine in pain characteristics, but the accompanying symptoms are rarely present. Cephalic large arteries are dilated during migraine headache as well as during NTG headache. N-acetylcysteine enhances the formation of NO and potentiates NTG-induced headache, whereas mepyramine, a H1-antagonist capable of blocking histamine-induced headache, has no effect. Thus, the headache is dependent on NO or other steps in the NO cascade. The model is useful for pharmacological interventions and sumatriptan reduced the NTG-induced headache. The NTG model may be a valuable tool in the development of future migraine drugs.

KW - Cerebrovascular Circulation

KW - Dose-Response Relationship, Drug

KW - Headache

KW - Hemodynamics

KW - Humans

KW - Models, Neurological

KW - Nitroglycerin

M3 - Journal article

C2 - 7585924

VL - 15

SP - 281

EP - 287

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 4

ER -

ID: 128984198