Experimental headache in humans
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Experimental headache in humans. / Iversen, Helle Klingenberg.
In: Cephalalgia : an international journal of headache, Vol. 15, No. 4, 1995, p. 281-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Experimental headache in humans
AU - Iversen, Helle Klingenberg
PY - 1995
Y1 - 1995
N2 - The need for valid human experimental models of headache is obvious. Several compounds have been proposed as headache-inducing agents, but only the nitroglycerin (NTG) model has been validated. In healthy subjects, intravenous infusions of the nitric oxide (NO) donor NTG induce a dose-dependent headache and dilatation of the temporal, radial and middle cerebral artery. NTG-induced headache, although less intense, resembles migraine in pain characteristics, but the accompanying symptoms are rarely present. Cephalic large arteries are dilated during migraine headache as well as during NTG headache. N-acetylcysteine enhances the formation of NO and potentiates NTG-induced headache, whereas mepyramine, a H1-antagonist capable of blocking histamine-induced headache, has no effect. Thus, the headache is dependent on NO or other steps in the NO cascade. The model is useful for pharmacological interventions and sumatriptan reduced the NTG-induced headache. The NTG model may be a valuable tool in the development of future migraine drugs.
AB - The need for valid human experimental models of headache is obvious. Several compounds have been proposed as headache-inducing agents, but only the nitroglycerin (NTG) model has been validated. In healthy subjects, intravenous infusions of the nitric oxide (NO) donor NTG induce a dose-dependent headache and dilatation of the temporal, radial and middle cerebral artery. NTG-induced headache, although less intense, resembles migraine in pain characteristics, but the accompanying symptoms are rarely present. Cephalic large arteries are dilated during migraine headache as well as during NTG headache. N-acetylcysteine enhances the formation of NO and potentiates NTG-induced headache, whereas mepyramine, a H1-antagonist capable of blocking histamine-induced headache, has no effect. Thus, the headache is dependent on NO or other steps in the NO cascade. The model is useful for pharmacological interventions and sumatriptan reduced the NTG-induced headache. The NTG model may be a valuable tool in the development of future migraine drugs.
KW - Cerebrovascular Circulation
KW - Dose-Response Relationship, Drug
KW - Headache
KW - Hemodynamics
KW - Humans
KW - Models, Neurological
KW - Nitroglycerin
M3 - Journal article
C2 - 7585924
VL - 15
SP - 281
EP - 287
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 4
ER -
ID: 128984198