Exhaustion measured by the SF-36 vitality scale is associated with a flattened diurnal cortisol profile
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Exhaustion measured by the SF-36 vitality scale is associated with a flattened diurnal cortisol profile. / Lindeberg, Sara I; Eek, Frida; Lindbladh, Eva; Ostergren, Per-Olof; Hansen, Ase Marie; Karlson, Björn; Hansen, Åse Marie.
In: Psychoneuroendocrinology, Vol. 33, No. 4, 2008, p. 471-477.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exhaustion measured by the SF-36 vitality scale is associated with a flattened diurnal cortisol profile
AU - Lindeberg, Sara I
AU - Eek, Frida
AU - Lindbladh, Eva
AU - Ostergren, Per-Olof
AU - Hansen, Ase Marie
AU - Karlson, Björn
AU - Hansen, Åse Marie
PY - 2008
Y1 - 2008
N2 - The possible association between stress-related exhaustion and reduced activity in the hypothalamo-pituitary-adrenal (HPA) axis is increasingly in focus. The aim of the present study was to examine whether exhaustion measured in a non-patient population is associated with alterations in diurnal cortisol profile. The study population included 78 working individuals. The study group was dichotomised into exhausted and non-exhausted groups by means of the SF-36 vitality scale. Salivary cortisol was measured at three times during 1 workday: at awakening, 30min after awakening, and in the evening. The results showed that diurnal cortisol variation was significantly reduced in exhausted individuals. The difference in cortisol variation was mainly due to lowered morning cortisol in the exhausted group. Differences in cortisol levels at each sampling time or in mean diurnal output of cortisol were not statistically significant. The results would support the notion that exhaustion is associated with HPA axis hypoactivity as assessed by salivary cortisol. Furthermore, the SF-36 vitality provides a measure of exhaustion that may be useful in epidemiological studies in order to explore long-term health effects of stress-related exhaustion.
AB - The possible association between stress-related exhaustion and reduced activity in the hypothalamo-pituitary-adrenal (HPA) axis is increasingly in focus. The aim of the present study was to examine whether exhaustion measured in a non-patient population is associated with alterations in diurnal cortisol profile. The study population included 78 working individuals. The study group was dichotomised into exhausted and non-exhausted groups by means of the SF-36 vitality scale. Salivary cortisol was measured at three times during 1 workday: at awakening, 30min after awakening, and in the evening. The results showed that diurnal cortisol variation was significantly reduced in exhausted individuals. The difference in cortisol variation was mainly due to lowered morning cortisol in the exhausted group. Differences in cortisol levels at each sampling time or in mean diurnal output of cortisol were not statistically significant. The results would support the notion that exhaustion is associated with HPA axis hypoactivity as assessed by salivary cortisol. Furthermore, the SF-36 vitality provides a measure of exhaustion that may be useful in epidemiological studies in order to explore long-term health effects of stress-related exhaustion.
KW - Adult
KW - Analysis of Variance
KW - Case-Control Studies
KW - Circadian Rhythm
KW - Fatigue
KW - Female
KW - Humans
KW - Hydrocortisone
KW - Hypothalamo-Hypophyseal System
KW - Likelihood Functions
KW - Linear Models
KW - Male
KW - Middle Aged
KW - Pituitary-Adrenal System
KW - Psychiatric Status Rating Scales
KW - Reference Values
KW - Saliva
KW - Severity of Illness Index
KW - Stress, Physiological
U2 - 10.1016/j.psyneuen.2008.01.005
DO - 10.1016/j.psyneuen.2008.01.005
M3 - Journal article
C2 - 18295411
VL - 33
SP - 471
EP - 477
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
IS - 4
ER -
ID: 10759177