Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities. / Jensen, Anders A.; Fahlke, Christoph; Bjørn-Yoshimoto, Walden Emil; Bunch, Lennart.

In: Current Opinion in Pharmacology, Vol. 20, 2015, p. 116-123.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, AA, Fahlke, C, Bjørn-Yoshimoto, WE & Bunch, L 2015, 'Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities', Current Opinion in Pharmacology, vol. 20, pp. 116-123. https://doi.org/10.1016/j.coph.2014.10.008

APA

Jensen, A. A., Fahlke, C., Bjørn-Yoshimoto, W. E., & Bunch, L. (2015). Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities. Current Opinion in Pharmacology, 20, 116-123. https://doi.org/10.1016/j.coph.2014.10.008

Vancouver

Jensen AA, Fahlke C, Bjørn-Yoshimoto WE, Bunch L. Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities. Current Opinion in Pharmacology. 2015;20:116-123. https://doi.org/10.1016/j.coph.2014.10.008

Author

Jensen, Anders A. ; Fahlke, Christoph ; Bjørn-Yoshimoto, Walden Emil ; Bunch, Lennart. / Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities. In: Current Opinion in Pharmacology. 2015 ; Vol. 20. pp. 116-123.

Bibtex

@article{5279d49f4210433f80b321f0fc0c4fde,
title = "Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities",
abstract = "The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the physiological functions mediated by the different transporter subtypes and their respective therapeutic potential have so far been sparse, in no small part due to the limited selection of pharmacological tools available. In the present update, we outline important new insights into the molecular compositions of EAATs and their intricate transport process, the novel approaches to pharmacological modulation of the transporters that have emerged, and interesting new perspectives in EAAT as drug targets proposed in recent years.",
author = "Jensen, {Anders A.} and Christoph Fahlke and Bj{\o}rn-Yoshimoto, {Walden Emil} and Lennart Bunch",
year = "2015",
doi = "10.1016/j.coph.2014.10.008",
language = "English",
volume = "20",
pages = "116--123",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

AU - Jensen, Anders A.

AU - Fahlke, Christoph

AU - Bjørn-Yoshimoto, Walden Emil

AU - Bunch, Lennart

PY - 2015

Y1 - 2015

N2 - The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the physiological functions mediated by the different transporter subtypes and their respective therapeutic potential have so far been sparse, in no small part due to the limited selection of pharmacological tools available. In the present update, we outline important new insights into the molecular compositions of EAATs and their intricate transport process, the novel approaches to pharmacological modulation of the transporters that have emerged, and interesting new perspectives in EAAT as drug targets proposed in recent years.

AB - The five excitatory amino acid transporters (EAAT1–5) mediating the synaptic uptake of the major excitatory neurotransmitter glutamate are differently expressed throughout the CNS and at the synaptic level. Although EAATs are crucial for normal excitatory neurotransmission, explorations into the physiological functions mediated by the different transporter subtypes and their respective therapeutic potential have so far been sparse, in no small part due to the limited selection of pharmacological tools available. In the present update, we outline important new insights into the molecular compositions of EAATs and their intricate transport process, the novel approaches to pharmacological modulation of the transporters that have emerged, and interesting new perspectives in EAAT as drug targets proposed in recent years.

U2 - 10.1016/j.coph.2014.10.008

DO - 10.1016/j.coph.2014.10.008

M3 - Journal article

C2 - 25466154

VL - 20

SP - 116

EP - 123

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

ER -

ID: 125640673