Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7

Research output: Contribution to journalJournal articlepeer-review

  • Mette Falkenberg Krantz
  • Hjorthøj, Carsten
  • Ditte Ellersgaard
  • Nicoline Hemager
  • Camilla Christiani
  • Katrine Soborg Spang
  • Birgitte Klee Burton
  • Maja Gregersen
  • Anne Sondergaard
  • Aja Greve
  • Jessica Ohland
  • Preben Bo Mortensen
  • Kerstin Jessica Plessen
  • Vibeke Bliksted
  • Jens Richardt Mollegaard Jepsen
  • Thorup, Anne Amalie Elgaard
  • Ole Mors
  • Nordentoft, Merete

Purpose Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.

Methods Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.

Results In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0 .04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (p

Conclusions Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.

Original languageEnglish
JournalSocial Psychiatry and Psychiatric Epidemiology
Pages (from-to)113-140
Number of pages28
Publication statusPublished - 2023

    Research areas

  • Familial high-risk, Severe parental mental illness, Socio-economy, Representativity, Generalizability, PSYCHIATRIC-DISORDERS, METAANALYSIS, PARENTS, NEUROCOGNITION, NONRESPONSE, IMPAIRMENTS, RELIABILITY, INVENTORY, REGISTRY, VERSION

ID: 319650057