TY - JOUR

T1 - ESMO Consensus Conference on malignant lymphoma

T2 - General perspectives and recommendations for the clinical management of the elderly patient with malignant lymphoma

AU - Buske, C.

AU - Hutchings, M.

AU - Ladetto, M.

AU - Goede, V.

AU - Mey, U.

AU - Soubeyran, P.

AU - Spina, M.

AU - Stauder, R.

AU - Trněný, M.

AU - Wedding, U.

AU - Fields, P.

AU - Dreyling, Martin

AU - Ferreri, Andrés J.M.

AU - Gaidano, Gianluca

AU - Le Gouill, Steven

AU - Luminari, Stefano

AU - de Nully Brown, Peter

AU - Pfreundschuh, Michael

AU - Pott, Christiane

AU - Schmitz, Norbert

AU - Balari, Anna Sureda

AU - van Imhoff, Gustaaf

AU - Walewski, Jan

AU - Zamò, Alberto

AU - Zucca, Emanuele

AU - The ESMO Lymphoma Consensus Conference Panel Members

PY - 2018

Y1 - 2018

N2 - The European Society for Medical Oncology (ESMO) consensus conference on mature B cell lymphomas and chronic lymphocytic leukaemia (CLL) was held on 20 June 2015 in Lugano, Switzerland, and included a multidisciplinary panel of 25 leading experts. The aimof the conference was to develop recommendations on critical subjects difficult to consider in detail in the ESMO Clinical Practice Guidelines. The following areas were identified: (1) the elderly patient, (2) prognostic factors suitable for clinical use, and (3) the 'ultra-high-risk' group. Before the conference, the expert panel was divided into three working groups; each group focused on one of these areas in order to address clinically-relevant questions relating to that topic. All relevant scientific literature, as identified by the experts, was reviewed in advance. During the consensus conference, each working group developed recommendations to address each of the four questions assigned to their group. These recommendations were presented to the entire panel and a consensus was reached. This consensus, which was further developed in continuous post-meeting discussions, formed the basis of three manuscripts, each covering one of the three key areas identified. This manuscript presents the consensus recommendations regarding the clinical management of elderly patients diagnosed with malignant lymphoma. Four clinically-relevant topics identified by the panel were: 1) how to define patient fitness, 2) assessing quality of life, 3) diagnostic work-up and 4) clinical management of elderly patients with lymphoma. Each of these key topics is addressed in the context of five different lymphoma entities, namely: CLL, follicular lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma and diffuse large B-cell lymphoma. Results, including a summary of evidence supporting each recommendation, are detailed in thismanuscript.

AB - The European Society for Medical Oncology (ESMO) consensus conference on mature B cell lymphomas and chronic lymphocytic leukaemia (CLL) was held on 20 June 2015 in Lugano, Switzerland, and included a multidisciplinary panel of 25 leading experts. The aimof the conference was to develop recommendations on critical subjects difficult to consider in detail in the ESMO Clinical Practice Guidelines. The following areas were identified: (1) the elderly patient, (2) prognostic factors suitable for clinical use, and (3) the 'ultra-high-risk' group. Before the conference, the expert panel was divided into three working groups; each group focused on one of these areas in order to address clinically-relevant questions relating to that topic. All relevant scientific literature, as identified by the experts, was reviewed in advance. During the consensus conference, each working group developed recommendations to address each of the four questions assigned to their group. These recommendations were presented to the entire panel and a consensus was reached. This consensus, which was further developed in continuous post-meeting discussions, formed the basis of three manuscripts, each covering one of the three key areas identified. This manuscript presents the consensus recommendations regarding the clinical management of elderly patients diagnosed with malignant lymphoma. Four clinically-relevant topics identified by the panel were: 1) how to define patient fitness, 2) assessing quality of life, 3) diagnostic work-up and 4) clinical management of elderly patients with lymphoma. Each of these key topics is addressed in the context of five different lymphoma entities, namely: CLL, follicular lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma and diffuse large B-cell lymphoma. Results, including a summary of evidence supporting each recommendation, are detailed in thismanuscript.

KW - Consensus

KW - Diagnosis

KW - Elderly patient

KW - Lymphoma

KW - Quality of life

KW - Treatment

U2 - 10.1093/annonc/mdx413

DO - 10.1093/annonc/mdx413

M3 - Journal article

C2 - 29194473

AN - SCOPUS:85046069858

VL - 29

SP - 544

EP - 562

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 3

ER -