Epigenetic therapy in hematological cancers
Research output: Contribution to journal › Review › Research › peer-review
Standard
Epigenetic therapy in hematological cancers. / Dimopoulos, Konstantinos; Grønbæk, Kirsten.
In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Vol. 127, No. 5, 2019, p. 316-328.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Epigenetic therapy in hematological cancers
AU - Dimopoulos, Konstantinos
AU - Grønbæk, Kirsten
N1 - Special Issue: Personalized Medicine
PY - 2019
Y1 - 2019
N2 - The increasing depth of knowledge about cancer biology throughout the last decades, has underlined the importance of not only genetic aberrations, but also epigenetic abnormalities in cancer cells. The extensive exploration of the cancer epigenome has provided insights into key pathways involved in tumorigenesis, as well as has allowed the development of novel epigenetic therapies. In this review, we will present the important role of epigenetic alterations in hematological diseases, with special focus on epigenetically-based targeting of hematological malignancies.
AB - The increasing depth of knowledge about cancer biology throughout the last decades, has underlined the importance of not only genetic aberrations, but also epigenetic abnormalities in cancer cells. The extensive exploration of the cancer epigenome has provided insights into key pathways involved in tumorigenesis, as well as has allowed the development of novel epigenetic therapies. In this review, we will present the important role of epigenetic alterations in hematological diseases, with special focus on epigenetically-based targeting of hematological malignancies.
KW - DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors
KW - DNA Methylation
KW - Epigenesis, Genetic
KW - Hematologic Neoplasms/drug therapy
KW - Histone Deacetylase Inhibitors/therapeutic use
KW - Histones/metabolism
KW - Humans
U2 - 10.1111/apm.12906
DO - 10.1111/apm.12906
M3 - Review
C2 - 30859683
VL - 127
SP - 316
EP - 328
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 5
ER -
ID: 225953976