Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance?
Research output: Contribution to journal › Journal article › Research › peer-review
A recent study shows that high expression of the efflux-pump AcrAB-TolC, which increases antibiotic tolerance, reduces DNA mismatch repair in Escherichia coli to promote spontaneous mutations. Because mutations in target genes can lead to high-level resistance, this highlights how transiently tolerant cells can develop resistance in response to antibiotic treatment.
Original language | English |
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Journal | Trends in Microbiology |
Volume | 27 |
Issue number | 4 |
Pages (from-to) | 291-293 |
ISSN | 0966-842X |
DOIs | |
Publication status | Published - 2019 |
ID: 214126264