Effects of tofacitinib on cardiovascular risk factors and cardiovascular outcomes based on phase III and long-term extension data in patients with plaque psoriasis
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Psoriasis is a systemic inflammatory condition that is associated with a higher risk of cardiovascular (CV) disease. Tofacitinib is being investigated as a treatment for psoriasis.
OBJECTIVE: We sought to evaluate the effects of tofacitinib on CV risk factors and major adverse CV events (MACEs) in patients with plaque psoriasis.
METHODS: Changes in select CV risk factors and the incidence rate (IR) of MACEs were evaluated in patients who were treated with tofacitinib.
RESULTS: Tofacitinib treatment was associated with small, dose-dependent increases in total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol, while the total/HDL cholesterol ratio was unchanged. There were no changes in blood pressure and glycated hemoglobin levels; C-reactive protein levels decreased. The IRs of a MACE were low and similar for both tofacitinib doses. Among 3623 subjects treated with tofacitinib, the total patient-years of exposure was 5204, with a median follow-up of 527 days, and the IR of MACEs was 0.37 (95% confidence interval, 0.22-0.57) patients with events per 100 patient-years.
LIMITATIONS: There was relatively short follow-up time for patients who had MACEs.
CONCLUSIONS: While treatment with tofacitinib is associated with a small increase in cholesterol levels, the total/HDL cholesterol ratio does not change, there are no unfavorable changes in several CV risk factors, and the incidence of MACEs is low.
Original language | English |
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Journal | Journal of the American Academy of Dermatology |
Volume | 75 |
Issue number | 5 |
Pages (from-to) | 897-905 |
Number of pages | 9 |
ISSN | 0190-9622 |
DOIs | |
Publication status | Published - Nov 2016 |
- Adult, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Cholesterol, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Comorbidity, Dyslipidemias, Female, Hemoglobin A, Glycosylated, Humans, Male, Metabolic Syndrome X, Middle Aged, Piperidines, Protein Kinase Inhibitors, Psoriasis, Pyrimidines, Pyrroles, Risk Factors, Treatment Outcome, Triglycerides, Journal Article
Research areas
ID: 177054476