Effects of the vasopressin agonist terlipressin on plasma cAMP and ENaC excretion in the urine in patients with cirrhosis and water retention
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Effects of the vasopressin agonist terlipressin on plasma cAMP and ENaC excretion in the urine in patients with cirrhosis and water retention. / Krag, Aleksander; Pedersen, Erling B; Møller, Søren; Bendtsen, Flemming; Pedersen, Erling.
In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 71, No. 2, 04.2011, p. 112-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of the vasopressin agonist terlipressin on plasma cAMP and ENaC excretion in the urine in patients with cirrhosis and water retention
AU - Krag, Aleksander
AU - Pedersen, Erling B
AU - Møller, Søren
AU - Bendtsen, Flemming
AU - Pedersen, Erling
PY - 2011/4
Y1 - 2011/4
N2 - Terlipressin is a vasopressin analogue used for its potent V1a effects in cirrhotic patients. Recent data suggest that terlipressin has affinity to renal V2 receptors and modulates Aquaporin 2 (AQP2) expression and free water clearance. Stimulation of renal V2 receptors may also affect sodium transport via the Epithelial Sodium Channel (ENaC). Furthermore, endothelial V2 receptors may indirectly affect proximal sodium handling by increasing plasma cAMP.
AB - Terlipressin is a vasopressin analogue used for its potent V1a effects in cirrhotic patients. Recent data suggest that terlipressin has affinity to renal V2 receptors and modulates Aquaporin 2 (AQP2) expression and free water clearance. Stimulation of renal V2 receptors may also affect sodium transport via the Epithelial Sodium Channel (ENaC). Furthermore, endothelial V2 receptors may indirectly affect proximal sodium handling by increasing plasma cAMP.
U2 - 10.3109/00365513.2010.537369
DO - 10.3109/00365513.2010.537369
M3 - Journal article
C2 - 21080762
VL - 71
SP - 112
EP - 116
JO - Scandinavian Journal of Clinical & Laboratory Investigation
JF - Scandinavian Journal of Clinical & Laboratory Investigation
SN - 0036-5513
IS - 2
ER -
ID: 34106548