Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis

Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis: A randomised study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis : A randomised study. / Hobolth, Lise; Bendtsen, Flemming; Hansen, Erik F; Møller, Søren.

In: Digestive and Liver Disease, Vol. 46, No. 3, 03.2014, p. 251-256.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hobolth, L, Bendtsen, F, Hansen, EF & Møller, S 2014, 'Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis: A randomised study', Digestive and Liver Disease, vol. 46, no. 3, pp. 251-256. https://doi.org/10.1016/j.dld.2013.10.013

APA

Hobolth, L., Bendtsen, F., Hansen, E. F., & Møller, S. (2014). Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis: A randomised study. Digestive and Liver Disease, 46(3), 251-256. https://doi.org/10.1016/j.dld.2013.10.013

Vancouver

Hobolth L, Bendtsen F, Hansen EF, Møller S. Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis: A randomised study. Digestive and Liver Disease. 2014 Mar;46(3):251-256. https://doi.org/10.1016/j.dld.2013.10.013

Author

Hobolth, Lise ; Bendtsen, Flemming ; Hansen, Erik F ; Møller, Søren. / Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis : A randomised study. In: Digestive and Liver Disease. 2014 ; Vol. 46, No. 3. pp. 251-256.

Bibtex

@article{dc7555c7cfbf40e19746d262eb3d1214,

title = "Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis: A randomised study",

abstract = "BACKGROUND AND AIMS: Newer studies suggest that carvedilol, a beta-blocker with a moderate anti-alpha-1 activity, is superior to propranolol in reducing the portal pressure and risk of variceal bleeding. The effect on arterial blood pressure is a matter of concern especially in decompensated patients.AIMS: to assess potential differential effects of beta-blockers and beta-blockers with moderate anti-alpha-1 activity on selected haemodynamic, humoral, and respiratory characteristics in cirrhosis.METHODS: Patients with cirrhosis and portal hypertension were randomised to receive carvedilol (n=16) or propranolol (n=13). Cardiac, systemic and splanchnic parameters along with oxygen saturation and plasma renin were measured at inclusion and after 3 months.RESULTS: Arterial blood pressure, heart rate, and cardiac output decreased equally, central circulation time and systemic vascular resistance increased significantly but similarly. Central blood volume, plasma volume and arterial compliance were unaltered. The QTc interval and renin levels decreased in the carvedilol group, however not significantly different from the propranolol group. Arterial oxygen saturation and alveolar arterial oxygen gradient remained constant in both groups. Hepatic venous pressure gradient decreased equally in the carvedilol and propranolol groups (-17% and -20%, non significant).CONCLUSIONS: Systemic haemodynamics and pulmonary effects of carvedilol and propranolol are modest and this study could not demonstrate any significant difference between the two treatments.",

keywords = "Adrenergic alpha-1 Receptor Antagonists, Adrenergic beta-Antagonists, Arteries, Blood Pressure, Blood Volume, Carbazoles, Cardiac Output, Compliance, Female, Heart Rate, Hemodynamics, Humans, Hypertension, Portal, Liver Circulation, Liver Cirrhosis, Male, Middle Aged, Oximetry, Plasma Volume, Portal Pressure, Propanolamines, Propranolol, Renin, Treatment Outcome, Vascular Resistance",

author = "Lise Hobolth and Flemming Bendtsen and Hansen, {Erik F} and S{\o}ren M{\o}ller",

year = "2014",

month = mar,

doi = "10.1016/j.dld.2013.10.013",

language = "English",

volume = "46",

pages = "251--256",

journal = "Rendiconti di Gastro-Enterologia",

issn = "1590-8658",

publisher = "W.B.Saunders Co. Ltd.",

number = "3",

}

RIS

TY - JOUR

T1 - Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis

T2 - A randomised study

AU - Hobolth, Lise

AU - Bendtsen, Flemming

AU - Hansen, Erik F

AU - Møller, Søren

PY - 2014/3

Y1 - 2014/3

N2 - BACKGROUND AND AIMS: Newer studies suggest that carvedilol, a beta-blocker with a moderate anti-alpha-1 activity, is superior to propranolol in reducing the portal pressure and risk of variceal bleeding. The effect on arterial blood pressure is a matter of concern especially in decompensated patients.AIMS: to assess potential differential effects of beta-blockers and beta-blockers with moderate anti-alpha-1 activity on selected haemodynamic, humoral, and respiratory characteristics in cirrhosis.METHODS: Patients with cirrhosis and portal hypertension were randomised to receive carvedilol (n=16) or propranolol (n=13). Cardiac, systemic and splanchnic parameters along with oxygen saturation and plasma renin were measured at inclusion and after 3 months.RESULTS: Arterial blood pressure, heart rate, and cardiac output decreased equally, central circulation time and systemic vascular resistance increased significantly but similarly. Central blood volume, plasma volume and arterial compliance were unaltered. The QTc interval and renin levels decreased in the carvedilol group, however not significantly different from the propranolol group. Arterial oxygen saturation and alveolar arterial oxygen gradient remained constant in both groups. Hepatic venous pressure gradient decreased equally in the carvedilol and propranolol groups (-17% and -20%, non significant).CONCLUSIONS: Systemic haemodynamics and pulmonary effects of carvedilol and propranolol are modest and this study could not demonstrate any significant difference between the two treatments.

AB - BACKGROUND AND AIMS: Newer studies suggest that carvedilol, a beta-blocker with a moderate anti-alpha-1 activity, is superior to propranolol in reducing the portal pressure and risk of variceal bleeding. The effect on arterial blood pressure is a matter of concern especially in decompensated patients.AIMS: to assess potential differential effects of beta-blockers and beta-blockers with moderate anti-alpha-1 activity on selected haemodynamic, humoral, and respiratory characteristics in cirrhosis.METHODS: Patients with cirrhosis and portal hypertension were randomised to receive carvedilol (n=16) or propranolol (n=13). Cardiac, systemic and splanchnic parameters along with oxygen saturation and plasma renin were measured at inclusion and after 3 months.RESULTS: Arterial blood pressure, heart rate, and cardiac output decreased equally, central circulation time and systemic vascular resistance increased significantly but similarly. Central blood volume, plasma volume and arterial compliance were unaltered. The QTc interval and renin levels decreased in the carvedilol group, however not significantly different from the propranolol group. Arterial oxygen saturation and alveolar arterial oxygen gradient remained constant in both groups. Hepatic venous pressure gradient decreased equally in the carvedilol and propranolol groups (-17% and -20%, non significant).CONCLUSIONS: Systemic haemodynamics and pulmonary effects of carvedilol and propranolol are modest and this study could not demonstrate any significant difference between the two treatments.

KW - Adrenergic alpha-1 Receptor Antagonists

KW - Adrenergic beta-Antagonists

KW - Arteries

KW - Blood Pressure

KW - Blood Volume

KW - Carbazoles

KW - Cardiac Output

KW - Compliance

KW - Female

KW - Heart Rate

KW - Hemodynamics

KW - Humans

KW - Hypertension, Portal

KW - Liver Circulation

KW - Liver Cirrhosis

KW - Male

KW - Middle Aged

KW - Oximetry

KW - Plasma Volume

KW - Portal Pressure

KW - Propanolamines

KW - Propranolol

KW - Renin

KW - Treatment Outcome

KW - Vascular Resistance

U2 - 10.1016/j.dld.2013.10.013

DO - 10.1016/j.dld.2013.10.013

M3 - Journal article

C2 - 24290869

VL - 46

SP - 251

EP - 256

JO - Rendiconti di Gastro-Enterologia

JF - Rendiconti di Gastro-Enterologia

SN - 1590-8658

IS - 3

ER -

ID: 138778887