Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A post hoc Analysis of the U-TURN Trial

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Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes : A post hoc Analysis of the U-TURN Trial. / Abildgaard, Julie; Johansen, Mette Yun; Skov-Jeppesen, Kirsa; Andersen, Lars Bo; Karstoft, Kristian; Hansen, Katrine Bagge; Hartmann, Bolette; Holst, Jens Juul; Pedersen, Bente Klarlund; Ried-Larsen, Mathias.

In: Medicine and Science in Sports and Exercise, 08.2021.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Abildgaard, J, Johansen, MY, Skov-Jeppesen, K, Andersen, LB, Karstoft, K, Hansen, KB, Hartmann, B, Holst, JJ, Pedersen, BK & Ried-Larsen, M 2021, 'Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A post hoc Analysis of the U-TURN Trial', Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0000000000002776

APA

Abildgaard, J., Johansen, M. Y., Skov-Jeppesen, K., Andersen, L. B., Karstoft, K., Hansen, K. B., Hartmann, B., Holst, J. J., Pedersen, B. K., & Ried-Larsen, M. (2021). Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A post hoc Analysis of the U-TURN Trial. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0000000000002776

Vancouver

Abildgaard J, Johansen MY, Skov-Jeppesen K, Andersen LB, Karstoft K, Hansen KB et al. Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A post hoc Analysis of the U-TURN Trial. Medicine and Science in Sports and Exercise. 2021 Aug. https://doi.org/10.1249/MSS.0000000000002776

Author

Abildgaard, Julie ; Johansen, Mette Yun ; Skov-Jeppesen, Kirsa ; Andersen, Lars Bo ; Karstoft, Kristian ; Hansen, Katrine Bagge ; Hartmann, Bolette ; Holst, Jens Juul ; Pedersen, Bente Klarlund ; Ried-Larsen, Mathias. / Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes : A post hoc Analysis of the U-TURN Trial. In: Medicine and Science in Sports and Exercise. 2021.

Bibtex

@article{051e5cd51aa047a3a452d50048cc3fe0,
title = "Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A post hoc Analysis of the U-TURN Trial",
abstract = "Introduction/Purpose.The increased risk of fractures with type 2 diabetes (T2D) is suggested to be caused by decreased bone turnover. Current international guidelines recommend lifestyle modifications, including exercise, as first-line treatment for T2D. The aim of this study was to investigate the effects of an exercise-based lifestyle intervention on bone turnover and bone mineral density (BMD) in persons with T2D.METHODS: Persons with T2D were randomized to either a 12-months lifestyle intervention (n = 64) or standard care (n = 34). The lifestyle intervention included five to six weekly aerobic training sessions, half of them combined with resistance training. Serum markers of bone turnover (osteocalcin (OC), N-terminal propeptide of type-I procollagen (PINP), reflecting bone formation, and carboxyterminal collagen I crosslinks (CTX-I), reflecting bone resorption) and BMD (by DXA) were measured before the intervention and at follow-up.RESULTS: From baseline to follow-up, s-PINP increased by 34 % (95 % CI: 17 - 50 %), s-CTX-I by 36 % (95 % CI: 1 - 71 %), and s-OC by 31 % (95 % CI: 11 - 51 %) more in the lifestyle intervention group compared with standard care. Loss of weight and fat mass were the strongest mediators of the increased bone turnover. BMD was unaffected by the intervention ([INCREMENT] BMD: 0.1 %, 95 % CI: -1.1 to 1.2 %).CONCLUSIONS: A 12-months intensive exercise-based lifestyle intervention led to a substantial but balanced increase in bone turnover in persons with T2D. The increased bone turnover combined with a preserved BMD, despite a considerable weight loss, is likely to reflect improved bone health and warrants further studies addressing the impact of exercise on risk of fractures in persons with T2D.",
author = "Julie Abildgaard and Johansen, {Mette Yun} and Kirsa Skov-Jeppesen and Andersen, {Lars Bo} and Kristian Karstoft and Hansen, {Katrine Bagge} and Bolette Hartmann and Holst, {Jens Juul} and Pedersen, {Bente Klarlund} and Mathias Ried-Larsen",
note = "Copyright {\textcopyright} 2021 American College of Sports Medicine.",
year = "2021",
month = aug,
doi = "10.1249/MSS.0000000000002776",
language = "English",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams & Wilkins",

}

RIS

TY - JOUR

T1 - Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes

T2 - A post hoc Analysis of the U-TURN Trial

AU - Abildgaard, Julie

AU - Johansen, Mette Yun

AU - Skov-Jeppesen, Kirsa

AU - Andersen, Lars Bo

AU - Karstoft, Kristian

AU - Hansen, Katrine Bagge

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Pedersen, Bente Klarlund

AU - Ried-Larsen, Mathias

N1 - Copyright © 2021 American College of Sports Medicine.

PY - 2021/8

Y1 - 2021/8

N2 - Introduction/Purpose.The increased risk of fractures with type 2 diabetes (T2D) is suggested to be caused by decreased bone turnover. Current international guidelines recommend lifestyle modifications, including exercise, as first-line treatment for T2D. The aim of this study was to investigate the effects of an exercise-based lifestyle intervention on bone turnover and bone mineral density (BMD) in persons with T2D.METHODS: Persons with T2D were randomized to either a 12-months lifestyle intervention (n = 64) or standard care (n = 34). The lifestyle intervention included five to six weekly aerobic training sessions, half of them combined with resistance training. Serum markers of bone turnover (osteocalcin (OC), N-terminal propeptide of type-I procollagen (PINP), reflecting bone formation, and carboxyterminal collagen I crosslinks (CTX-I), reflecting bone resorption) and BMD (by DXA) were measured before the intervention and at follow-up.RESULTS: From baseline to follow-up, s-PINP increased by 34 % (95 % CI: 17 - 50 %), s-CTX-I by 36 % (95 % CI: 1 - 71 %), and s-OC by 31 % (95 % CI: 11 - 51 %) more in the lifestyle intervention group compared with standard care. Loss of weight and fat mass were the strongest mediators of the increased bone turnover. BMD was unaffected by the intervention ([INCREMENT] BMD: 0.1 %, 95 % CI: -1.1 to 1.2 %).CONCLUSIONS: A 12-months intensive exercise-based lifestyle intervention led to a substantial but balanced increase in bone turnover in persons with T2D. The increased bone turnover combined with a preserved BMD, despite a considerable weight loss, is likely to reflect improved bone health and warrants further studies addressing the impact of exercise on risk of fractures in persons with T2D.

AB - Introduction/Purpose.The increased risk of fractures with type 2 diabetes (T2D) is suggested to be caused by decreased bone turnover. Current international guidelines recommend lifestyle modifications, including exercise, as first-line treatment for T2D. The aim of this study was to investigate the effects of an exercise-based lifestyle intervention on bone turnover and bone mineral density (BMD) in persons with T2D.METHODS: Persons with T2D were randomized to either a 12-months lifestyle intervention (n = 64) or standard care (n = 34). The lifestyle intervention included five to six weekly aerobic training sessions, half of them combined with resistance training. Serum markers of bone turnover (osteocalcin (OC), N-terminal propeptide of type-I procollagen (PINP), reflecting bone formation, and carboxyterminal collagen I crosslinks (CTX-I), reflecting bone resorption) and BMD (by DXA) were measured before the intervention and at follow-up.RESULTS: From baseline to follow-up, s-PINP increased by 34 % (95 % CI: 17 - 50 %), s-CTX-I by 36 % (95 % CI: 1 - 71 %), and s-OC by 31 % (95 % CI: 11 - 51 %) more in the lifestyle intervention group compared with standard care. Loss of weight and fat mass were the strongest mediators of the increased bone turnover. BMD was unaffected by the intervention ([INCREMENT] BMD: 0.1 %, 95 % CI: -1.1 to 1.2 %).CONCLUSIONS: A 12-months intensive exercise-based lifestyle intervention led to a substantial but balanced increase in bone turnover in persons with T2D. The increased bone turnover combined with a preserved BMD, despite a considerable weight loss, is likely to reflect improved bone health and warrants further studies addressing the impact of exercise on risk of fractures in persons with T2D.

U2 - 10.1249/MSS.0000000000002776

DO - 10.1249/MSS.0000000000002776

M3 - Journal article

C2 - 34431828

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

ER -

ID: 279260195