Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases: A Parental Negative Control Study

Research output: Contribution to journalJournal articleResearchpeer-review

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Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases : A Parental Negative Control Study. / Taylor, Kurt; Elhakeem, Ahmed; Thorbjørnsrud Nader, Johanna Lucia; Yang, Tiffany C; Isaevska, Elena; Richiardi, Lorenzo; Vrijkotte, Tanja; Pinot de Moira, Angela; Murray, Deirdre M; Finn, Daragh; Mason, Dan; Wright, John; Oddie, Sam; Roeleveld, Nel; Harris, Jennifer R; Andersen, Anne-Marie Nybo; Caputo, Massimo; Lawlor, Deborah A.

In: Journal of the American Heart Association, Vol. 10, e020051, 2021.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Taylor, K, Elhakeem, A, Thorbjørnsrud Nader, JL, Yang, TC, Isaevska, E, Richiardi, L, Vrijkotte, T, Pinot de Moira, A, Murray, DM, Finn, D, Mason, D, Wright, J, Oddie, S, Roeleveld, N, Harris, JR, Andersen, A-MN, Caputo, M & Lawlor, DA 2021, 'Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases: A Parental Negative Control Study', Journal of the American Heart Association, vol. 10, e020051. https://doi.org/10.1161/JAHA.120.020051

APA

Taylor, K., Elhakeem, A., Thorbjørnsrud Nader, J. L., Yang, T. C., Isaevska, E., Richiardi, L., Vrijkotte, T., Pinot de Moira, A., Murray, D. M., Finn, D., Mason, D., Wright, J., Oddie, S., Roeleveld, N., Harris, J. R., Andersen, A-M. N., Caputo, M., & Lawlor, D. A. (2021). Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases: A Parental Negative Control Study. Journal of the American Heart Association, 10, [e020051]. https://doi.org/10.1161/JAHA.120.020051

Vancouver

Taylor K, Elhakeem A, Thorbjørnsrud Nader JL, Yang TC, Isaevska E, Richiardi L et al. Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases: A Parental Negative Control Study. Journal of the American Heart Association. 2021;10. e020051. https://doi.org/10.1161/JAHA.120.020051

Author

Taylor, Kurt ; Elhakeem, Ahmed ; Thorbjørnsrud Nader, Johanna Lucia ; Yang, Tiffany C ; Isaevska, Elena ; Richiardi, Lorenzo ; Vrijkotte, Tanja ; Pinot de Moira, Angela ; Murray, Deirdre M ; Finn, Daragh ; Mason, Dan ; Wright, John ; Oddie, Sam ; Roeleveld, Nel ; Harris, Jennifer R ; Andersen, Anne-Marie Nybo ; Caputo, Massimo ; Lawlor, Deborah A. / Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases : A Parental Negative Control Study. In: Journal of the American Heart Association. 2021 ; Vol. 10.

Bibtex

@article{e33b672fc8114f4bbaa88b653f7510bc,
title = "Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases: A Parental Negative Control Study",
abstract = "Background Congenital heart diseases (CHDs) are the most common congenital anomaly. The causes of CHDs are largely unknown. Higher prenatal body mass index (BMI), smoking, and alcohol consumption are associated with increased risk of CHDs. Whether these are causal is unclear. Methods and Results Seven European birth cohorts, including 232 390 offspring (2469 CHD cases [1.1%]), were included. We applied negative exposure paternal control analyses to explore the intrauterine effects of maternal BMI, smoking, and alcohol consumption during pregnancy, on offspring CHDs and CHD severity. We used logistic regression, adjusting for confounders and the other parent's exposure and combined estimates using a fixed-effects meta-analysis. In adjusted analyses, maternal overweight (odds ratio [OR], 1.15 [95% CI, 1.01-1.31]) and obesity (OR, 1.12 [95% CI, 0.93-1.36]), compared with normal weight, were associated with higher odds of CHD, but there was no clear evidence of a linear increase in odds across the whole BMI distribution. Associations of paternal overweight, obesity, and mean BMI were similar to the maternal associations. Maternal pregnancy smoking was associated with higher odds of CHD (OR, 1.11 [95% CI, 0.97-1.25]) but paternal smoking was not (OR, 0.96 [95% CI, 0.85-1.07]). The positive association with maternal smoking appeared to be driven by nonsevere CHD cases (OR, 1.22 [95% CI, 1.04-1.44]). Associations with maternal moderate/heavy pregnancy alcohol consumption were imprecisely estimated (OR, 1.16 [95% CI, 0.52-2.58]) and similar to those for paternal consumption. Conclusions We found evidence of an intrauterine effect for maternal smoking on offspring CHDs, but no evidence for higher maternal BMI or alcohol consumption. Our findings provide further support for the importance of smoking cessation during pregnancy.",
author = "Kurt Taylor and Ahmed Elhakeem and {Thorbj{\o}rnsrud Nader}, {Johanna Lucia} and Yang, {Tiffany C} and Elena Isaevska and Lorenzo Richiardi and Tanja Vrijkotte and {Pinot de Moira}, Angela and Murray, {Deirdre M} and Daragh Finn and Dan Mason and John Wright and Sam Oddie and Nel Roeleveld and Harris, {Jennifer R} and Andersen, {Anne-Marie Nybo} and Massimo Caputo and Lawlor, {Deborah A}",
year = "2021",
doi = "10.1161/JAHA.120.020051",
language = "English",
volume = "10",
journal = "American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease",
issn = "2047-9980",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Effect of Maternal Prepregnancy/Early-Pregnancy Body Mass Index and Pregnancy Smoking and Alcohol on Congenital Heart Diseases

T2 - A Parental Negative Control Study

AU - Taylor, Kurt

AU - Elhakeem, Ahmed

AU - Thorbjørnsrud Nader, Johanna Lucia

AU - Yang, Tiffany C

AU - Isaevska, Elena

AU - Richiardi, Lorenzo

AU - Vrijkotte, Tanja

AU - Pinot de Moira, Angela

AU - Murray, Deirdre M

AU - Finn, Daragh

AU - Mason, Dan

AU - Wright, John

AU - Oddie, Sam

AU - Roeleveld, Nel

AU - Harris, Jennifer R

AU - Andersen, Anne-Marie Nybo

AU - Caputo, Massimo

AU - Lawlor, Deborah A

PY - 2021

Y1 - 2021

N2 - Background Congenital heart diseases (CHDs) are the most common congenital anomaly. The causes of CHDs are largely unknown. Higher prenatal body mass index (BMI), smoking, and alcohol consumption are associated with increased risk of CHDs. Whether these are causal is unclear. Methods and Results Seven European birth cohorts, including 232 390 offspring (2469 CHD cases [1.1%]), were included. We applied negative exposure paternal control analyses to explore the intrauterine effects of maternal BMI, smoking, and alcohol consumption during pregnancy, on offspring CHDs and CHD severity. We used logistic regression, adjusting for confounders and the other parent's exposure and combined estimates using a fixed-effects meta-analysis. In adjusted analyses, maternal overweight (odds ratio [OR], 1.15 [95% CI, 1.01-1.31]) and obesity (OR, 1.12 [95% CI, 0.93-1.36]), compared with normal weight, were associated with higher odds of CHD, but there was no clear evidence of a linear increase in odds across the whole BMI distribution. Associations of paternal overweight, obesity, and mean BMI were similar to the maternal associations. Maternal pregnancy smoking was associated with higher odds of CHD (OR, 1.11 [95% CI, 0.97-1.25]) but paternal smoking was not (OR, 0.96 [95% CI, 0.85-1.07]). The positive association with maternal smoking appeared to be driven by nonsevere CHD cases (OR, 1.22 [95% CI, 1.04-1.44]). Associations with maternal moderate/heavy pregnancy alcohol consumption were imprecisely estimated (OR, 1.16 [95% CI, 0.52-2.58]) and similar to those for paternal consumption. Conclusions We found evidence of an intrauterine effect for maternal smoking on offspring CHDs, but no evidence for higher maternal BMI or alcohol consumption. Our findings provide further support for the importance of smoking cessation during pregnancy.

AB - Background Congenital heart diseases (CHDs) are the most common congenital anomaly. The causes of CHDs are largely unknown. Higher prenatal body mass index (BMI), smoking, and alcohol consumption are associated with increased risk of CHDs. Whether these are causal is unclear. Methods and Results Seven European birth cohorts, including 232 390 offspring (2469 CHD cases [1.1%]), were included. We applied negative exposure paternal control analyses to explore the intrauterine effects of maternal BMI, smoking, and alcohol consumption during pregnancy, on offspring CHDs and CHD severity. We used logistic regression, adjusting for confounders and the other parent's exposure and combined estimates using a fixed-effects meta-analysis. In adjusted analyses, maternal overweight (odds ratio [OR], 1.15 [95% CI, 1.01-1.31]) and obesity (OR, 1.12 [95% CI, 0.93-1.36]), compared with normal weight, were associated with higher odds of CHD, but there was no clear evidence of a linear increase in odds across the whole BMI distribution. Associations of paternal overweight, obesity, and mean BMI were similar to the maternal associations. Maternal pregnancy smoking was associated with higher odds of CHD (OR, 1.11 [95% CI, 0.97-1.25]) but paternal smoking was not (OR, 0.96 [95% CI, 0.85-1.07]). The positive association with maternal smoking appeared to be driven by nonsevere CHD cases (OR, 1.22 [95% CI, 1.04-1.44]). Associations with maternal moderate/heavy pregnancy alcohol consumption were imprecisely estimated (OR, 1.16 [95% CI, 0.52-2.58]) and similar to those for paternal consumption. Conclusions We found evidence of an intrauterine effect for maternal smoking on offspring CHDs, but no evidence for higher maternal BMI or alcohol consumption. Our findings provide further support for the importance of smoking cessation during pregnancy.

U2 - 10.1161/JAHA.120.020051

DO - 10.1161/JAHA.120.020051

M3 - Journal article

C2 - 34039012

VL - 10

JO - American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease

JF - American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease

SN - 2047-9980

M1 - e020051

ER -

ID: 270423139