Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities
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Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities. / Norgaard, Ane; Jensen-Dahm, Christina; Wimberley, Theresa; Svendsen, Jesper Hastrup; Ishtiak-Ahmed, Kazi; Laursen, Thomas Munk; Waldemar, Gunhild; Gasse, Christiane.
In: Journal of the American Geriatrics Society, Vol. 70, No. 4, 2022, p. 1169-1179.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities
AU - Norgaard, Ane
AU - Jensen-Dahm, Christina
AU - Wimberley, Theresa
AU - Svendsen, Jesper Hastrup
AU - Ishtiak-Ahmed, Kazi
AU - Laursen, Thomas Munk
AU - Waldemar, Gunhild
AU - Gasse, Christiane
PY - 2022
Y1 - 2022
N2 - Background We investigated the mortality risk associated with the initiation of antipsychotic treatment among patients with dementia and whether comorbidities related to the cardiovascular system and diabetes interact with antipsychotic treatment to increase the mortality risk beyond the risk of death independently associated with antipsychotics and comorbidity alone. Methods We designed a matched cohort study using nationwide registry data. All Danish residents aged 65-95 years diagnosed with dementia between 2009 and 2014 were included. Dementia was assessed as a first-time registered dementia diagnosis in the Danish National Patient Register or the Danish Psychiatric Central Research Register and/or a first-time prescription for antidementia medication. Patients exposed to antipsychotics were matched with up to three unexposed patients. Cox proportional hazards models were used to compare rates of death within 180 days after the initiation of antipsychotic treatment. The models were adjusted for potential confounders. Analyses were stratified for diabetes, heart disease, and cerebrovascular disease, and we calculated the relative excess risk due to interaction (RERI). Results The study cohort included 8244 exposed patients and 24,730 unexposed patients. A total of 5938 patients died during the first 180 days of follow-up. Patients exposed to antipsychotics had a significantly higher adjusted risk of death (hazard ratio: 1.35, 95% confidence interval: 1.27-1.43) than unexposed patients. Crude mortality rates were higher among patients with heart disease and diabetes when antipsychotic treatment was initiated compared with patients without comorbidities. Relative risk estimates did not differ between patients with and without heart disease, cerebrovascular disease, and diabetes, and RERI suggested no positive additive interaction. Risk analysis suggested higher mortality in patients without cerebrovascular disease who initiated antipsychotics. Conclusion This nationwide study adds to the evidence that antipsychotic treatment is associated with increased mortality and suggests that attention should be paid to all initiators of antipsychotics irrespective of cardiovascular disease and diabetes.
AB - Background We investigated the mortality risk associated with the initiation of antipsychotic treatment among patients with dementia and whether comorbidities related to the cardiovascular system and diabetes interact with antipsychotic treatment to increase the mortality risk beyond the risk of death independently associated with antipsychotics and comorbidity alone. Methods We designed a matched cohort study using nationwide registry data. All Danish residents aged 65-95 years diagnosed with dementia between 2009 and 2014 were included. Dementia was assessed as a first-time registered dementia diagnosis in the Danish National Patient Register or the Danish Psychiatric Central Research Register and/or a first-time prescription for antidementia medication. Patients exposed to antipsychotics were matched with up to three unexposed patients. Cox proportional hazards models were used to compare rates of death within 180 days after the initiation of antipsychotic treatment. The models were adjusted for potential confounders. Analyses were stratified for diabetes, heart disease, and cerebrovascular disease, and we calculated the relative excess risk due to interaction (RERI). Results The study cohort included 8244 exposed patients and 24,730 unexposed patients. A total of 5938 patients died during the first 180 days of follow-up. Patients exposed to antipsychotics had a significantly higher adjusted risk of death (hazard ratio: 1.35, 95% confidence interval: 1.27-1.43) than unexposed patients. Crude mortality rates were higher among patients with heart disease and diabetes when antipsychotic treatment was initiated compared with patients without comorbidities. Relative risk estimates did not differ between patients with and without heart disease, cerebrovascular disease, and diabetes, and RERI suggested no positive additive interaction. Risk analysis suggested higher mortality in patients without cerebrovascular disease who initiated antipsychotics. Conclusion This nationwide study adds to the evidence that antipsychotic treatment is associated with increased mortality and suggests that attention should be paid to all initiators of antipsychotics irrespective of cardiovascular disease and diabetes.
KW - antipsychotics
KW - cardiovascular disease
KW - dementia
KW - diabetes
KW - mortality
KW - PSYCHOTROPIC MEDICATIONS
KW - OLDER-ADULTS
KW - DEATH
KW - METAANALYSIS
KW - HOSPITALIZATION
KW - OUTCOMES
KW - EVENTS
U2 - 10.1111/jgs.17623
DO - 10.1111/jgs.17623
M3 - Journal article
C2 - 35029305
VL - 70
SP - 1169
EP - 1179
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
IS - 4
ER -
ID: 290454187