Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice
Research output: Contribution to journal › Journal article › Research › peer-review
3'-Deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use (18)F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative effects of the experimental chemotherapy Top216 non-invasively by PET.
| Original language | English |
|---|---|
| Journal | P L o S One |
| Volume | 5 |
| Issue number | 9 |
| Pages (from-to) | e12965 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - 1 Jan 2010 |
- Animals, Antineoplastic Agents, Cell Proliferation, Dideoxynucleosides, Disease Models, Animal, Drug Monitoring, Female, Fluorodeoxyglucose F18, Humans, Mice, Mice, Nude, Ovarian Neoplasms, Positron-Emission Tomography, Radiopharmaceuticals, Xenograft Model Antitumor Assays
Research areas
ID: 34044950