Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites. / Van Baar, Annieke C.G.; Prodan, Andrei; Wahlgren, Camilla D.; Poulsen, Steen S.; Knop, Filip K.; Groen, Albert K.; Bergman, Jacques J.; Nieuwdorp, Max; Levin, Evgeni.
In: Endocrine Connections, Vol. 7, No. 5, 2018, p. 673-680.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites
AU - Van Baar, Annieke C.G.
AU - Prodan, Andrei
AU - Wahlgren, Camilla D.
AU - Poulsen, Steen S.
AU - Knop, Filip K.
AU - Groen, Albert K.
AU - Bergman, Jacques J.
AU - Nieuwdorp, Max
AU - Levin, Evgeni
PY - 2018
Y1 - 2018
N2 - Background: Enteroendocrine cells are essential for the regulation of glucose metabolism, but it is unknown whether they are associated with clinical features of metabolic syndrome (MetS) and fasting plasma metabolites. Objective: We aimed to identify fasting plasma metabolites that associate with duodenal L cell, K cell and delta cell densities in subjects with MetS with ranging levels of insulin resistance. Research design and methods: In this cross-sectional study, we evaluated L, K and delta cell density in duodenal biopsies from treatment-naïve males with MetS using machinelearning methodology. Results: We identified specific clinical biomarkers and plasma metabolites associated with L cell and delta cell density. L cell density was associated with increased plasma metabolite levels including symmetrical dimethylarginine, 3-aminoisobutyric acid, kynurenine and glycine. In turn, these L cell-linked fasting plasma metabolites correlated with clinical features of MetS. Conclusions: Our results indicate a link between duodenal L cells, plasma metabolites and clinical characteristics of MetS. We conclude that duodenal L cells associate with plasma metabolites that have been implicated in human glucose metabolism homeostasis. Disentangling the causal relation between L cells and these metabolites might help to improve the (small intestinal-driven) pathophysiology behind insulin resistance in human obesity.
AB - Background: Enteroendocrine cells are essential for the regulation of glucose metabolism, but it is unknown whether they are associated with clinical features of metabolic syndrome (MetS) and fasting plasma metabolites. Objective: We aimed to identify fasting plasma metabolites that associate with duodenal L cell, K cell and delta cell densities in subjects with MetS with ranging levels of insulin resistance. Research design and methods: In this cross-sectional study, we evaluated L, K and delta cell density in duodenal biopsies from treatment-naïve males with MetS using machinelearning methodology. Results: We identified specific clinical biomarkers and plasma metabolites associated with L cell and delta cell density. L cell density was associated with increased plasma metabolite levels including symmetrical dimethylarginine, 3-aminoisobutyric acid, kynurenine and glycine. In turn, these L cell-linked fasting plasma metabolites correlated with clinical features of MetS. Conclusions: Our results indicate a link between duodenal L cells, plasma metabolites and clinical characteristics of MetS. We conclude that duodenal L cells associate with plasma metabolites that have been implicated in human glucose metabolism homeostasis. Disentangling the causal relation between L cells and these metabolites might help to improve the (small intestinal-driven) pathophysiology behind insulin resistance in human obesity.
KW - Enteroendocrine cells
KW - Incretins
KW - Machine-learning methodology
KW - Metabolic syndrome
KW - Plasma metabolites
U2 - 10.1530/EC-18-0094
DO - 10.1530/EC-18-0094
M3 - Journal article
C2 - 29669802
AN - SCOPUS:85046899950
VL - 7
SP - 673
EP - 680
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 5
ER -
ID: 199323931