Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate

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Standard

Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate. / Iversen, Helle Klingenberg; Nielsen, T H; Garre, K; Tfelt-Hansen, P; Olesen, J.

In: European Journal of Clinical Pharmacology, Vol. 42, No. 1, 1992, p. 31-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Iversen, HK, Nielsen, TH, Garre, K, Tfelt-Hansen, P & Olesen, J 1992, 'Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate', European Journal of Clinical Pharmacology, vol. 42, no. 1, pp. 31-5.

APA

Iversen, H. K., Nielsen, T. H., Garre, K., Tfelt-Hansen, P., & Olesen, J. (1992). Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate. European Journal of Clinical Pharmacology, 42(1), 31-5.

Vancouver

Iversen HK, Nielsen TH, Garre K, Tfelt-Hansen P, Olesen J. Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate. European Journal of Clinical Pharmacology. 1992;42(1):31-5.

Author

Iversen, Helle Klingenberg ; Nielsen, T H ; Garre, K ; Tfelt-Hansen, P ; Olesen, J. / Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate. In: European Journal of Clinical Pharmacology. 1992 ; Vol. 42, No. 1. pp. 31-5.

Bibtex

@article{910ca99fec084c56b23fbd8c3995ad82,

title = "Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate",

abstract = "The aim of the present study was to compare the ability of different doses of isosorbide-5-mononitrate (5-ISMN) to cause dilatation of medium sized and small arteries, and to examine the intensity and duration of any headache produced. Ten healthy volunteers each received 3 doses of 5-ISMN and placebo on separate days. The diameters of the radial and superficial temporal arteries were repeatedly measured with high frequency ultrasound and pain was scored using a 10 point verbal scale. A clear dose-relationship was found for plasma concentrations and headache, and for changes in the diameter of the temporal artery, but not for the radial artery. It is concluded that headache after 5-ISMN is caused by arterial dilatation or by mechanisms responsible for the arterial dilatation. Ultrasound monitoring of arterial diameters is an important and sensitive tool in the evaluation of nitrates and other vasodilators.",

keywords = "Adult, Arteries, Dose-Response Relationship, Drug, Double-Blind Method, Forearm, Headache, Humans, Isosorbide Dinitrate, Multivariate Analysis, Random Allocation, Reference Values, Temporal Arteries, Vasodilation",

author = "Iversen, {Helle Klingenberg} and Nielsen, {T H} and K Garre and P Tfelt-Hansen and J Olesen",

year = "1992",

language = "English",

volume = "42",

pages = "31--5",

journal = "European Journal of Clinical Pharmacology",

issn = "0031-6970",

publisher = "Springer",

number = "1",

}

RIS

TY - JOUR

T1 - Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate

AU - Iversen, Helle Klingenberg

AU - Nielsen, T H

AU - Garre, K

AU - Tfelt-Hansen, P

AU - Olesen, J

PY - 1992

Y1 - 1992

N2 - The aim of the present study was to compare the ability of different doses of isosorbide-5-mononitrate (5-ISMN) to cause dilatation of medium sized and small arteries, and to examine the intensity and duration of any headache produced. Ten healthy volunteers each received 3 doses of 5-ISMN and placebo on separate days. The diameters of the radial and superficial temporal arteries were repeatedly measured with high frequency ultrasound and pain was scored using a 10 point verbal scale. A clear dose-relationship was found for plasma concentrations and headache, and for changes in the diameter of the temporal artery, but not for the radial artery. It is concluded that headache after 5-ISMN is caused by arterial dilatation or by mechanisms responsible for the arterial dilatation. Ultrasound monitoring of arterial diameters is an important and sensitive tool in the evaluation of nitrates and other vasodilators.

AB - The aim of the present study was to compare the ability of different doses of isosorbide-5-mononitrate (5-ISMN) to cause dilatation of medium sized and small arteries, and to examine the intensity and duration of any headache produced. Ten healthy volunteers each received 3 doses of 5-ISMN and placebo on separate days. The diameters of the radial and superficial temporal arteries were repeatedly measured with high frequency ultrasound and pain was scored using a 10 point verbal scale. A clear dose-relationship was found for plasma concentrations and headache, and for changes in the diameter of the temporal artery, but not for the radial artery. It is concluded that headache after 5-ISMN is caused by arterial dilatation or by mechanisms responsible for the arterial dilatation. Ultrasound monitoring of arterial diameters is an important and sensitive tool in the evaluation of nitrates and other vasodilators.

KW - Adult

KW - Arteries

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Forearm

KW - Headache

KW - Humans

KW - Isosorbide Dinitrate

KW - Multivariate Analysis

KW - Random Allocation

KW - Reference Values

KW - Temporal Arteries

KW - Vasodilation

M3 - Journal article

C2 - 1541314

VL - 42

SP - 31

EP - 35

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 1

ER -

ID: 128984657