Differential mitochondrial gene expression in adipose tissue following weight loss induced by diet or bariatric surgery
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Differential mitochondrial gene expression in adipose tissue following weight loss induced by diet or bariatric surgery. / van der Kolk, Birgitta W; Muniandy, Maheswary; Kaminska, Dorota; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Valsesia, Armand; Langin, Dominique; Vaittinen, Maija; Pääkkönen, Mirva; Jokinen, Riikka; Kaye, Sanna; Heinonen, Sini; Virtanen, Kirsi A; Andersson, Daniel P; Männistö, Ville; Saris, Wim H; Astrup, Arne; Rydén, Mikael; Blaak, Ellen E; Pajukanta, Päivi; Pihlajamäki, Jussi; Pietiläinen, Kirsi H.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 106, No. 5, 2021, p. 1312-1324.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Differential mitochondrial gene expression in adipose tissue following weight loss induced by diet or bariatric surgery
AU - van der Kolk, Birgitta W
AU - Muniandy, Maheswary
AU - Kaminska, Dorota
AU - Alvarez, Marcus
AU - Ko, Arthur
AU - Miao, Zong
AU - Valsesia, Armand
AU - Langin, Dominique
AU - Vaittinen, Maija
AU - Pääkkönen, Mirva
AU - Jokinen, Riikka
AU - Kaye, Sanna
AU - Heinonen, Sini
AU - Virtanen, Kirsi A
AU - Andersson, Daniel P
AU - Männistö, Ville
AU - Saris, Wim H
AU - Astrup, Arne
AU - Rydén, Mikael
AU - Blaak, Ellen E
AU - Pajukanta, Päivi
AU - Pihlajamäki, Jussi
AU - Pietiläinen, Kirsi H
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.
PY - 2021
Y1 - 2021
N2 - Context: Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown.Objective: Investigate how SAT mitochondria change following diet-induced and bariatric surgery-induced weight-loss interventions in four independent weight-loss studies.Methods: The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in two studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n=49) and 5-year (n = 37) follow-up.Results: Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; Ingenuity Pathway Analyses (IPA) z-scores: -8.7 following LCD, -4.4 following weight maintenance; CRYO: IPA z-score: -5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001).Conclusions: Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.
AB - Context: Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown.Objective: Investigate how SAT mitochondria change following diet-induced and bariatric surgery-induced weight-loss interventions in four independent weight-loss studies.Methods: The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in two studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n=49) and 5-year (n = 37) follow-up.Results: Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; Ingenuity Pathway Analyses (IPA) z-scores: -8.7 following LCD, -4.4 following weight maintenance; CRYO: IPA z-score: -5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001).Conclusions: Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.
KW - Faculty of Science
KW - Adipose tissue
KW - Mitochondria
KW - Weight loss
KW - Diet-induced
KW - Bariatric surgery
KW - Transcriptomics
U2 - 10.1210/clinem/dgab072
DO - 10.1210/clinem/dgab072
M3 - Journal article
C2 - 33560372
VL - 106
SP - 1312
EP - 1324
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 5
ER -
ID: 256630880