Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels
Research output: Contribution to journal › Journal article › Research › peer-review
K(v)11.1 channels are involved in regulating cellular excitability in various tissues including brain, heart and smooth muscle. In these tissues, at least two isoforms, K(v)11.1a and K(v)11.1b, with different kinetics, are expressed. K(v)11.1 activators are potential therapeutic agents, but their effects have only been tested on the K(v)11.1a isoform. In this study, the effects of two different K(v)11.1 activators, NS1643 and RPR260243, were characterized on K(v)11.1a and K(v)11.1b channels.
Original language | English |
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Journal | British Journal of Pharmacology |
Volume | 161 |
Issue number | 3 |
Pages (from-to) | 614-28 |
Number of pages | 15 |
DOIs | |
Publication status | Published - Oct 2010 |
- Animals, Cresols, Ether-A-Go-Go Potassium Channels, Membrane Potentials, Oocytes, Patch-Clamp Techniques, Phenylurea Compounds, Piperidines, Protein Isoforms, Quinolines, Transfection, Xenopus laevis
Research areas
ID: 45080993