Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs. / Pan, Xiaoyu; Gong, Desheng; Gao, Fei; Sangild, Per Torp.

In: Epigenomics, Vol. 10, No. 4, 01.04.2018, p. 395-408.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pan, X, Gong, D, Gao, F & Sangild, PT 2018, 'Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs', Epigenomics, vol. 10, no. 4, pp. 395-408. https://doi.org/10.2217/epi-2017-0122

APA

Pan, X., Gong, D., Gao, F., & Sangild, P. T. (2018). Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs. Epigenomics, 10(4), 395-408. https://doi.org/10.2217/epi-2017-0122

Vancouver

Pan X, Gong D, Gao F, Sangild PT. Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs. Epigenomics. 2018 Apr 1;10(4):395-408. https://doi.org/10.2217/epi-2017-0122

Author

Pan, Xiaoyu ; Gong, Desheng ; Gao, Fei ; Sangild, Per Torp. / Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs. In: Epigenomics. 2018 ; Vol. 10, No. 4. pp. 395-408.

Bibtex

@article{a98a6e9d3d1e4544a5f13e67a2ddedb7,
title = "Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs",
abstract = "AIM: To examine how enteral feeding affects the intestinal epigenome and gene expression just after preterm birth.MATERIALS & METHODS: Intestinal tissue from preterm pigs, modeling preterm infants, was collected at birth and 5 days after gradual introduction of infant formula or bovine colostrum. The intestinal tissue was analyzed by reduced representation bisulfite sequencing and real-time qPCR.RESULTS: Relative to colostrum, formula increased bacterial epithelial adherence and lipopolysaccharide binding protein (LBP) expression, which was regulated by promoter methylation. Diet-dependent changes in DNA methylation and/or mRNA expression were related to innate immune response, hypoxia, angiogenesis and epithelial-mesenchymal transition pathways (e.g., TTC38, IL8, C3, HIF1A and VEGFR1).CONCLUSION: Epigenetic changes may mediate important effects of the first feeding on intestinal development in preterm neonates.",
author = "Xiaoyu Pan and Desheng Gong and Fei Gao and Sangild, {Per Torp}",
year = "2018",
month = apr,
day = "1",
doi = "10.2217/epi-2017-0122",
language = "English",
volume = "10",
pages = "395--408",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs

AU - Pan, Xiaoyu

AU - Gong, Desheng

AU - Gao, Fei

AU - Sangild, Per Torp

PY - 2018/4/1

Y1 - 2018/4/1

N2 - AIM: To examine how enteral feeding affects the intestinal epigenome and gene expression just after preterm birth.MATERIALS & METHODS: Intestinal tissue from preterm pigs, modeling preterm infants, was collected at birth and 5 days after gradual introduction of infant formula or bovine colostrum. The intestinal tissue was analyzed by reduced representation bisulfite sequencing and real-time qPCR.RESULTS: Relative to colostrum, formula increased bacterial epithelial adherence and lipopolysaccharide binding protein (LBP) expression, which was regulated by promoter methylation. Diet-dependent changes in DNA methylation and/or mRNA expression were related to innate immune response, hypoxia, angiogenesis and epithelial-mesenchymal transition pathways (e.g., TTC38, IL8, C3, HIF1A and VEGFR1).CONCLUSION: Epigenetic changes may mediate important effects of the first feeding on intestinal development in preterm neonates.

AB - AIM: To examine how enteral feeding affects the intestinal epigenome and gene expression just after preterm birth.MATERIALS & METHODS: Intestinal tissue from preterm pigs, modeling preterm infants, was collected at birth and 5 days after gradual introduction of infant formula or bovine colostrum. The intestinal tissue was analyzed by reduced representation bisulfite sequencing and real-time qPCR.RESULTS: Relative to colostrum, formula increased bacterial epithelial adherence and lipopolysaccharide binding protein (LBP) expression, which was regulated by promoter methylation. Diet-dependent changes in DNA methylation and/or mRNA expression were related to innate immune response, hypoxia, angiogenesis and epithelial-mesenchymal transition pathways (e.g., TTC38, IL8, C3, HIF1A and VEGFR1).CONCLUSION: Epigenetic changes may mediate important effects of the first feeding on intestinal development in preterm neonates.

U2 - 10.2217/epi-2017-0122

DO - 10.2217/epi-2017-0122

M3 - Journal article

C2 - 29587528

VL - 10

SP - 395

EP - 408

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 4

ER -

ID: 198721240