Diagnostic Age, Age at Death and Stage Migration in Men Dying with or from Prostate Cancer in Denmark
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Diagnostic Age, Age at Death and Stage Migration in Men Dying with or from Prostate Cancer in Denmark. / Andersen, Marc Casper Meineche; Stroomberg, Hein Vincent; Brasso, Klaus; Helgstrand, John Thomas; Røder, Andreas.
In: Diagnostics, Vol. 12, No. 5, 1271, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Diagnostic Age, Age at Death and Stage Migration in Men Dying with or from Prostate Cancer in Denmark
AU - Andersen, Marc Casper Meineche
AU - Stroomberg, Hein Vincent
AU - Brasso, Klaus
AU - Helgstrand, John Thomas
AU - Røder, Andreas
N1 - Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022
Y1 - 2022
N2 - The impact of changes in diagnostic activity and treatment options on prostate cancer epidemiology remains a subject of debate. Newly published long-term survival outcomes may not represent contemporary patients and new perspectives are in demand. All men dying in Denmark with prostate cancer diagnosis during a 10-year period were analyzed to address the stage migration of and time lived with prostate cancer diagnosis. All male deaths in Denmark between 2007 and 2016 (n = 261,657) were obtained and crosslinked with The Danish Prostate Cancer Registry (DaPCaR) and the Danish Cancer Registry. Correlation in diagnostic age and stage (localized, locally advanced, metastatic), age at death and cause of death were investigated by Kruskal-Wallis test and linear regression in 15,692 men diagnosed with prostate cancer. Prostate cancer mortality remained stable during the study period. Among the men who died of prostate cancer, 65% had locally advanced or metastatic disease at diagnosis. Age at diagnosis declined in men diagnosed with localized disease and remained constant in men with locally advanced or metastatic disease. Age at death increased in all men. Despite increased efforts to detect prostate cancer early, two-thirds of men who die from prostate cancer still have advanced prostate cancer at the time of diagnosis. Our data show increased life-expectancy in men diagnosed with prostate cancer, however, this benefit must be weighed against increased time of living with the disease and overdiagnosis. The intensified treatment of elderly men and men with advanced disease may be the key to lower prostate cancer mortality.
AB - The impact of changes in diagnostic activity and treatment options on prostate cancer epidemiology remains a subject of debate. Newly published long-term survival outcomes may not represent contemporary patients and new perspectives are in demand. All men dying in Denmark with prostate cancer diagnosis during a 10-year period were analyzed to address the stage migration of and time lived with prostate cancer diagnosis. All male deaths in Denmark between 2007 and 2016 (n = 261,657) were obtained and crosslinked with The Danish Prostate Cancer Registry (DaPCaR) and the Danish Cancer Registry. Correlation in diagnostic age and stage (localized, locally advanced, metastatic), age at death and cause of death were investigated by Kruskal-Wallis test and linear regression in 15,692 men diagnosed with prostate cancer. Prostate cancer mortality remained stable during the study period. Among the men who died of prostate cancer, 65% had locally advanced or metastatic disease at diagnosis. Age at diagnosis declined in men diagnosed with localized disease and remained constant in men with locally advanced or metastatic disease. Age at death increased in all men. Despite increased efforts to detect prostate cancer early, two-thirds of men who die from prostate cancer still have advanced prostate cancer at the time of diagnosis. Our data show increased life-expectancy in men diagnosed with prostate cancer, however, this benefit must be weighed against increased time of living with the disease and overdiagnosis. The intensified treatment of elderly men and men with advanced disease may be the key to lower prostate cancer mortality.
KW - cause of death
KW - clinical characteristics
KW - Danish Prostate Cancer Registry (DaPCaR)
KW - prostatic neoplasms
KW - stage migration
U2 - 10.3390/diagnostics12051271
DO - 10.3390/diagnostics12051271
M3 - Journal article
C2 - 35626426
AN - SCOPUS:85130943156
VL - 12
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 5
M1 - 1271
ER -
ID: 326461823