Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder. / Veddum, Lotte; Greve, Aja Neergaard; Andreassen, Anna Krogh; Knudsen, Christina Bruun; Brandt, Julie Marie; Gregersen, Maja; Krantz, Mette Falkenberg; Søndergaard, Anne; Ohland, Jessica; Burton, Birgitte Klee; Jepsen, Jens Richardt Møllegaard; Hemager, Nicoline; Thorup, Anne Amalie Elgaard; Nordentoft, Merete; Mors, Ole; Bliksted, Vibeke.

In: Schizophrenia Research: Cognition, Vol. 28, 100242, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Veddum, L, Greve, AN, Andreassen, AK, Knudsen, CB, Brandt, JM, Gregersen, M, Krantz, MF, Søndergaard, A, Ohland, J, Burton, BK, Jepsen, JRM, Hemager, N, Thorup, AAE, Nordentoft, M, Mors, O & Bliksted, V 2022, 'Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder', Schizophrenia Research: Cognition, vol. 28, 100242. https://doi.org/10.1016/j.scog.2022.100242

APA

Veddum, L., Greve, A. N., Andreassen, A. K., Knudsen, C. B., Brandt, J. M., Gregersen, M., Krantz, M. F., Søndergaard, A., Ohland, J., Burton, B. K., Jepsen, J. R. M., Hemager, N., Thorup, A. A. E., Nordentoft, M., Mors, O., & Bliksted, V. (2022). Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder. Schizophrenia Research: Cognition, 28, [100242]. https://doi.org/10.1016/j.scog.2022.100242

Vancouver

Veddum L, Greve AN, Andreassen AK, Knudsen CB, Brandt JM, Gregersen M et al. Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder. Schizophrenia Research: Cognition. 2022;28. 100242. https://doi.org/10.1016/j.scog.2022.100242

Author

Veddum, Lotte ; Greve, Aja Neergaard ; Andreassen, Anna Krogh ; Knudsen, Christina Bruun ; Brandt, Julie Marie ; Gregersen, Maja ; Krantz, Mette Falkenberg ; Søndergaard, Anne ; Ohland, Jessica ; Burton, Birgitte Klee ; Jepsen, Jens Richardt Møllegaard ; Hemager, Nicoline ; Thorup, Anne Amalie Elgaard ; Nordentoft, Merete ; Mors, Ole ; Bliksted, Vibeke. / Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder. In: Schizophrenia Research: Cognition. 2022 ; Vol. 28.

Bibtex

@article{8217d86886e3466c8a6aa69446c53073,

title = "Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder",

abstract = "Social impairments are suggested as vulnerability markers for schizophrenia and bipolar disorder. Therefore, we investigated the development of social responsiveness and theory of mind (ToM) in children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP). This study is part of The Danish High Risk and Resilience Study, a longitudinal cohort study of children at FHR-SZ or FHR-BP and population-based controls (PBC). Social responsiveness was measured with the Social Responsiveness Scale (SRS-2), completed by teachers and primary caregivers. ToM was measured using The Animated Triangles Task (ATT). Both SRS-2 and ATT were applied at age 7 and 11. A total of 520 children participated (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 200). Results showed no significant time by group interactions. At follow-up, children at FHR-SZ exhibited impaired social responsiveness compared with PBC regardless of the informant. At both timepoints, a higher proportion of children at FHR-SZ were rated at a clinically significant level, implying inference in everyday social interactions. Compared with PBC, primary caregivers reported impairments in social responsiveness in children at FHR-BP at follow-up. The three groups did not differ in ToM at follow-up. Social responsiveness and ToM do not develop differently in children at FHR-SZ, FHR-BP and PBC from age 7 to 11, but impairments in social responsiveness remain stable and may constitute a vulnerability marker particularly in children at FHR-SZ, but also FHR-BP. ToM abilities seem to improve and remain intact, but ToM development and ToM task properties should be taken into consideration.",

keywords = "Bipolar disorder, High-risk, Offspring, Schizophrenia, Social responsiveness, Theory of mind",

author = "Lotte Veddum and Greve, {Aja Neergaard} and Andreassen, {Anna Krogh} and Knudsen, {Christina Bruun} and Brandt, {Julie Marie} and Maja Gregersen and Krantz, {Mette Falkenberg} and Anne S{\o}ndergaard and Jessica Ohland and Burton, {Birgitte Klee} and Jepsen, {Jens Richardt M{\o}llegaard} and Nicoline Hemager and Thorup, {Anne Amalie Elgaard} and Merete Nordentoft and Ole Mors and Vibeke Bliksted",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

doi = "10.1016/j.scog.2022.100242",

language = "English",

volume = "28",

journal = "Schizophrenia Research: Cognition",

issn = "2215-0013",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Development of social responsiveness and theory of mind in children of parents with schizophrenia or bipolar disorder

AU - Veddum, Lotte

AU - Greve, Aja Neergaard

AU - Andreassen, Anna Krogh

AU - Knudsen, Christina Bruun

AU - Brandt, Julie Marie

AU - Gregersen, Maja

AU - Krantz, Mette Falkenberg

AU - Søndergaard, Anne

AU - Ohland, Jessica

AU - Burton, Birgitte Klee

AU - Jepsen, Jens Richardt Møllegaard

AU - Hemager, Nicoline

AU - Thorup, Anne Amalie Elgaard

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Bliksted, Vibeke

PY - 2022

Y1 - 2022

N2 - Social impairments are suggested as vulnerability markers for schizophrenia and bipolar disorder. Therefore, we investigated the development of social responsiveness and theory of mind (ToM) in children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP). This study is part of The Danish High Risk and Resilience Study, a longitudinal cohort study of children at FHR-SZ or FHR-BP and population-based controls (PBC). Social responsiveness was measured with the Social Responsiveness Scale (SRS-2), completed by teachers and primary caregivers. ToM was measured using The Animated Triangles Task (ATT). Both SRS-2 and ATT were applied at age 7 and 11. A total of 520 children participated (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 200). Results showed no significant time by group interactions. At follow-up, children at FHR-SZ exhibited impaired social responsiveness compared with PBC regardless of the informant. At both timepoints, a higher proportion of children at FHR-SZ were rated at a clinically significant level, implying inference in everyday social interactions. Compared with PBC, primary caregivers reported impairments in social responsiveness in children at FHR-BP at follow-up. The three groups did not differ in ToM at follow-up. Social responsiveness and ToM do not develop differently in children at FHR-SZ, FHR-BP and PBC from age 7 to 11, but impairments in social responsiveness remain stable and may constitute a vulnerability marker particularly in children at FHR-SZ, but also FHR-BP. ToM abilities seem to improve and remain intact, but ToM development and ToM task properties should be taken into consideration.

AB - Social impairments are suggested as vulnerability markers for schizophrenia and bipolar disorder. Therefore, we investigated the development of social responsiveness and theory of mind (ToM) in children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP). This study is part of The Danish High Risk and Resilience Study, a longitudinal cohort study of children at FHR-SZ or FHR-BP and population-based controls (PBC). Social responsiveness was measured with the Social Responsiveness Scale (SRS-2), completed by teachers and primary caregivers. ToM was measured using The Animated Triangles Task (ATT). Both SRS-2 and ATT were applied at age 7 and 11. A total of 520 children participated (FHR-SZ, n = 201; FHR-BP, n = 119; PBC, n = 200). Results showed no significant time by group interactions. At follow-up, children at FHR-SZ exhibited impaired social responsiveness compared with PBC regardless of the informant. At both timepoints, a higher proportion of children at FHR-SZ were rated at a clinically significant level, implying inference in everyday social interactions. Compared with PBC, primary caregivers reported impairments in social responsiveness in children at FHR-BP at follow-up. The three groups did not differ in ToM at follow-up. Social responsiveness and ToM do not develop differently in children at FHR-SZ, FHR-BP and PBC from age 7 to 11, but impairments in social responsiveness remain stable and may constitute a vulnerability marker particularly in children at FHR-SZ, but also FHR-BP. ToM abilities seem to improve and remain intact, but ToM development and ToM task properties should be taken into consideration.

KW - Bipolar disorder

KW - High-risk

KW - Offspring

KW - Schizophrenia

KW - Social responsiveness

KW - Theory of mind

U2 - 10.1016/j.scog.2022.100242

DO - 10.1016/j.scog.2022.100242

M3 - Journal article

C2 - 35242611

AN - SCOPUS:85125130989

VL - 28

JO - Schizophrenia Research: Cognition

JF - Schizophrenia Research: Cognition

SN - 2215-0013

M1 - 100242

ER -

ID: 299556425