Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation
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Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation. / Herth, Matthias Manfred; Andersen, Valdemar L. ; Lehel, Szabolcs; Madsen, Jacob; Knudsen, Gitte Moos; Kristensen, Jesper Langgaard.
In: Chemical Communications, Vol. 49, 2013, p. 3805-3807.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation
AU - Herth, Matthias Manfred
AU - Andersen, Valdemar L.
AU - Lehel, Szabolcs
AU - Madsen, Jacob
AU - Knudsen, Gitte Moos
AU - Kristensen, Jesper Langgaard
PY - 2013
Y1 - 2013
N2 - Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.
AB - Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.
U2 - 10.1039/C3CC41027G
DO - 10.1039/C3CC41027G
M3 - Journal article
VL - 49
SP - 3805
EP - 3807
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
ER -
ID: 45105283