Cycling matters: Sex hormone regulation of vascular potassium channels
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Cycling matters : Sex hormone regulation of vascular potassium channels. / Baldwin, Samuel N.; Jepps, Thomas A.; Greenwood, Iain A.
In: Channels, Vol. 17, No. 1, 2217637, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Cycling matters
T2 - Sex hormone regulation of vascular potassium channels
AU - Baldwin, Samuel N.
AU - Jepps, Thomas A.
AU - Greenwood, Iain A.
PY - 2023
Y1 - 2023
N2 - Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic preclinical scientific research. Recent research by our own laboratory indicates that cyclical changes in serum concentrations of sex -hormones across the rat estrus cycle, primary estradiol, have significant consequences for the subcellular trafficking and function of KV. Vascular potassium channels, including KV, are essential components of vascular reactivity. Our study represents a small part of a growing field of literature aimed at determining the role of sex hormones in regulating arterial ion channel function. This review covers key findings describing the current understanding of sex hormone regulation of vascular potassium channels, with a focus on KV channels. Further, we highlight areas of research where the estrus cycle should be considered in future studies to determine the consequences of physiological oscillations in concentrations of sex hormones on vascular potassium channel function.
AB - Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic preclinical scientific research. Recent research by our own laboratory indicates that cyclical changes in serum concentrations of sex -hormones across the rat estrus cycle, primary estradiol, have significant consequences for the subcellular trafficking and function of KV. Vascular potassium channels, including KV, are essential components of vascular reactivity. Our study represents a small part of a growing field of literature aimed at determining the role of sex hormones in regulating arterial ion channel function. This review covers key findings describing the current understanding of sex hormone regulation of vascular potassium channels, with a focus on KV channels. Further, we highlight areas of research where the estrus cycle should be considered in future studies to determine the consequences of physiological oscillations in concentrations of sex hormones on vascular potassium channel function.
KW - estrogens
KW - estrus cycle
KW - ion channels
KW - progesterone
KW - testosterone
KW - vascular biology
UR - http://www.scopus.com/inward/record.url?scp=85160381212&partnerID=8YFLogxK
U2 - 10.1080/19336950.2023.2217637
DO - 10.1080/19336950.2023.2217637
M3 - Review
C2 - 37243715
AN - SCOPUS:85160381212
VL - 17
JO - Channels
JF - Channels
SN - 1933-6950
IS - 1
M1 - 2217637
ER -
ID: 353704211