Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

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Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels. / van der Horst, Jennifer; Greenwood, Iain A.; Jepps, Thomas A.

In: Frontiers in Physiology, Vol. 11, 727, 2020.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

van der Horst, J, Greenwood, IA & Jepps, TA 2020, 'Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels', Frontiers in Physiology, vol. 11, 727. https://doi.org/10.3389/fphys.2020.00727

APA

van der Horst, J., Greenwood, I. A., & Jepps, T. A. (2020). Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels. Frontiers in Physiology, 11, [727]. https://doi.org/10.3389/fphys.2020.00727

Vancouver

van der Horst J, Greenwood IA, Jepps TA. Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels. Frontiers in Physiology. 2020;11. 727. https://doi.org/10.3389/fphys.2020.00727

Author

van der Horst, Jennifer ; Greenwood, Iain A. ; Jepps, Thomas A. / Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels. In: Frontiers in Physiology. 2020 ; Vol. 11.

Bibtex

@article{5abfd13d59124ae08dfe8024aafe104f,

title = "Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels",

abstract = "Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.",

keywords = "cAMP, EPAC, Kv7 (KCNQ), physiology, PKA",

author = "{van der Horst}, Jennifer and Greenwood, {Iain A.} and Jepps, {Thomas A.}",

year = "2020",

doi = "10.3389/fphys.2020.00727",

language = "English",

volume = "11",

journal = "Frontiers in Physiology",

issn = "1664-042X",

publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

AU - van der Horst, Jennifer

AU - Greenwood, Iain A.

AU - Jepps, Thomas A.

PY - 2020

Y1 - 2020

N2 - Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.

AB - Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.

KW - cAMP

KW - EPAC

KW - Kv7 (KCNQ)

KW - physiology

KW - PKA

UR - http://www.scopus.com/inward/record.url?scp=85087916966&partnerID=8YFLogxK

U2 - 10.3389/fphys.2020.00727

DO - 10.3389/fphys.2020.00727

M3 - Review

C2 - 32695022

AN - SCOPUS:85087916966

VL - 11

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 727

ER -

ID: 246823050