Current radiosynthesis strategies for 5-HT2A receptor PET tracers
Research output: Contribution to journal › Journal article › Research › peer-review
Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2A R positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.
Original language | English |
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Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 58 |
Issue number | 7 |
Pages (from-to) | 265-73 |
Number of pages | 9 |
ISSN | 0362-4803 |
DOIs | |
Publication status | Published - 15 Jun 2015 |
ID: 151556875