C-Terminal lactamization of peptides
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C-Terminal lactamization of peptides. / Fischer, Niklas H.; Nielsen, Daniel S.; Palmer, Daniel; Meldal, Morten; Diness, Frederik.
In: Chemical Communications, Vol. 57, No. 7, 2021, p. 895-898.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - C-Terminal lactamization of peptides
AU - Fischer, Niklas H.
AU - Nielsen, Daniel S.
AU - Palmer, Daniel
AU - Meldal, Morten
AU - Diness, Frederik
PY - 2021
Y1 - 2021
N2 - Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.
AB - Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.
U2 - 10.1039/D0CC06018F
DO - 10.1039/D0CC06018F
M3 - Journal article
VL - 57
SP - 895
EP - 898
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 7
ER -
ID: 261160414