Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity
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Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity. / Chadha, Preet S; Jepps, Thomas A; Carr, Georgina; Stott, Jennifer B; Zhu, Hei-Lei; Cole, William C; Greenwood, Iain A.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 34, No. 4, 04.2014, p. 887-93.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related Peptide-induced cerebral reactivity
AU - Chadha, Preet S
AU - Jepps, Thomas A
AU - Carr, Georgina
AU - Stott, Jennifer B
AU - Zhu, Hei-Lei
AU - Cole, William C
AU - Greenwood, Iain A
PY - 2014/4
Y1 - 2014/4
N2 - Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. The present study investigated the contribution of Kv7.4 and Kv7.5 isoforms to myogenic and CGRP regulation of MCA diameter and determined whether they were affected in hypertensive animals.
AB - Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP). Previous studies showed that MCAs express KCNQ1, 4, and 5 potassium channel genes, and the expression products (Kv7 channels) participate in the myogenic control of MCA diameter. The present study investigated the contribution of Kv7.4 and Kv7.5 isoforms to myogenic and CGRP regulation of MCA diameter and determined whether they were affected in hypertensive animals.
U2 - 10.1161/ATVBAHA.114.303405
DO - 10.1161/ATVBAHA.114.303405
M3 - Journal article
C2 - 24558103
VL - 34
SP - 887
EP - 893
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 4
ER -
ID: 104942948