Consequence of insertion trauma - effect on early measurements when using intracerebral devices
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Consequence of insertion trauma - effect on early measurements when using intracerebral devices. / Andelius, Ted Carl Kejlberg; Pedersen, Mette Vestergård; Bøgh, Nikolaj; Omann, Camilla; Hjortdal, Vibeke Elisabeth; Pedersen, Michael; Kyng, Kasper Jacobsen; Henriksen, Tine Brink.
In: Scientific Reports, Vol. 9, No. 1, 10652, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Consequence of insertion trauma - effect on early measurements when using intracerebral devices
AU - Andelius, Ted Carl Kejlberg
AU - Pedersen, Mette Vestergård
AU - Bøgh, Nikolaj
AU - Omann, Camilla
AU - Hjortdal, Vibeke Elisabeth
AU - Pedersen, Michael
AU - Kyng, Kasper Jacobsen
AU - Henriksen, Tine Brink
PY - 2019
Y1 - 2019
N2 - There are a variety of devices that quantify biological properties of cerebral tissue. Installing such device will cause a local insertion trauma, which will affect early measurements. Current literature proposes minimum one hour of observation before acquiring first measurements when using microdialysis. It is unknown whether this applies to other intracerebral devices. We therefore aimed to investigate time needed to reach steady state when using microdialysis and two intracerebral probes in a piglet model. Ten newborn piglets less than 24 hours of age were anaesthetized. Two probes (Codman and OxyLite/OxyFlo) and a microdialysis catheter (CMA Microdialysis) were installed 10 mm into the left hemisphere. Probes measured intracranial pressure, cerebral blood flow, and oxygen tension. The microdialysis catheter measured lactate, glucose, glycerol, and pyruvate. Measurements were acquired hourly for 20 hours. Lactate and glycerol peaked immediately after insertion and reached steady state after approximately four hours. Glucose, pyruvate, cerebral blood flow, and intracranial pressure reached steady state immediately. Oxygen tension reached steady state after 12 hours. With time, interindividual variability decreased for the majority of measurements. Consequently, time to stabilization after insertion depends on the choice of device and is crucial to obtain valid baseline values with high degree of precision.
AB - There are a variety of devices that quantify biological properties of cerebral tissue. Installing such device will cause a local insertion trauma, which will affect early measurements. Current literature proposes minimum one hour of observation before acquiring first measurements when using microdialysis. It is unknown whether this applies to other intracerebral devices. We therefore aimed to investigate time needed to reach steady state when using microdialysis and two intracerebral probes in a piglet model. Ten newborn piglets less than 24 hours of age were anaesthetized. Two probes (Codman and OxyLite/OxyFlo) and a microdialysis catheter (CMA Microdialysis) were installed 10 mm into the left hemisphere. Probes measured intracranial pressure, cerebral blood flow, and oxygen tension. The microdialysis catheter measured lactate, glucose, glycerol, and pyruvate. Measurements were acquired hourly for 20 hours. Lactate and glycerol peaked immediately after insertion and reached steady state after approximately four hours. Glucose, pyruvate, cerebral blood flow, and intracranial pressure reached steady state immediately. Oxygen tension reached steady state after 12 hours. With time, interindividual variability decreased for the majority of measurements. Consequently, time to stabilization after insertion depends on the choice of device and is crucial to obtain valid baseline values with high degree of precision.
U2 - 10.1038/s41598-019-47052-4
DO - 10.1038/s41598-019-47052-4
M3 - Journal article
C2 - 31337819
VL - 9
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 10652
ER -
ID: 241755543