COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents
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COMU : scope and limitations of the latest innovation in peptide acyl transfer reagents. / Subirós-Funosas, Ramon; Nieto-Rodriguez, Lidia; Jensen, Knud Jørgen; Albericio, Fernando.
In: Journal of Peptide Science, Vol. 19, No. 7, 2013, p. 408-414.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - COMU
T2 - scope and limitations of the latest innovation in peptide acyl transfer reagents
AU - Subirós-Funosas, Ramon
AU - Nieto-Rodriguez, Lidia
AU - Jensen, Knud Jørgen
AU - Albericio, Fernando
N1 - Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd.
PY - 2013
Y1 - 2013
N2 - The methodology for peptide bond formation is undergoing a continuous evolution where the main actors are being renewed. In recent years, coupling reagents based on the Oxyma scaffold, such as the uronium salt COMU, has been a groundbreaking contribution to the field. The advantages of COMU over classic benzotriazole-based reagents (HATU, HBTU, HCTU, TBTU) were proven in terms of solubility and coupling efficiency in bulky junctions in our groups and others. However, some aspects of the use of COMU need to be revised and improved, such as the stability of commercial samples in organic solvents, which hampers the compatibility with long synthesis in automated synthesizers. In this review, an overview of the main features and suggestions to improve the use of COMU are presented, along with a discussion on the best conditions for its use in microwave-assisted peptide robots.
AB - The methodology for peptide bond formation is undergoing a continuous evolution where the main actors are being renewed. In recent years, coupling reagents based on the Oxyma scaffold, such as the uronium salt COMU, has been a groundbreaking contribution to the field. The advantages of COMU over classic benzotriazole-based reagents (HATU, HBTU, HCTU, TBTU) were proven in terms of solubility and coupling efficiency in bulky junctions in our groups and others. However, some aspects of the use of COMU need to be revised and improved, such as the stability of commercial samples in organic solvents, which hampers the compatibility with long synthesis in automated synthesizers. In this review, an overview of the main features and suggestions to improve the use of COMU are presented, along with a discussion on the best conditions for its use in microwave-assisted peptide robots.
U2 - 10.1002/psc.2517
DO - 10.1002/psc.2517
M3 - Journal article
C2 - 23712932
VL - 19
SP - 408
EP - 414
JO - Journal of Peptide Science
JF - Journal of Peptide Science
SN - 1075-2617
IS - 7
ER -
ID: 99345129